HIV-1 evolution under pressure of protease inhibitors: climbing the stairs of viral fitness

B. Berkhout

doi:https://doi.org/10.1007/BF02253518

HIV-1 evolution under pressure of protease inhibitors: climbing the stairs of viral fitness

B. Berkhout

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Abstract

The human immunodeficiency virus (HIV-1) has evolved into a viral quasispecies with a high replication capacity or fitness. Antiretroviral drugs potently inhibit replication of the wild-type virus, but HIV-1 responds by selection of drug-resistant variants. Here we review, in brief, the evolution of resistance to protease inhibitors that is characterized by severe fitness losses and an abundance of subsequent repair strategies. The possibility to restrict HIV-1 fitness is discussed in relation to the control of HIV-1 pathogenesis

Original language	Undefined/Unknown
Pages (from-to)	298-305
Journal	Journal of biomedical science
Volume	6
Issue number	5
DOIs	https://doi.org/10.1007/BF02253518
Publication status	Published - 1999

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https://doi.org/10.1007/BF02253518

https://pure.uva.nl/ws/files/3304110/6708_76044.pdf

Cite this

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title = "HIV-1 evolution under pressure of protease inhibitors: climbing the stairs of viral fitness",

abstract = "The human immunodeficiency virus (HIV-1) has evolved into a viral quasispecies with a high replication capacity or fitness. Antiretroviral drugs potently inhibit replication of the wild-type virus, but HIV-1 responds by selection of drug-resistant variants. Here we review, in brief, the evolution of resistance to protease inhibitors that is characterized by severe fitness losses and an abundance of subsequent repair strategies. The possibility to restrict HIV-1 fitness is discussed in relation to the control of HIV-1 pathogenesis",

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