HIV Type 1 transmission networks among men having sex with men and heterosexuals in Kenya

Daniela Bezemer; Nuno Rodrigues Faria; Amin Hassan; Raph L. Hamers; Gaudensia Mutua; Omu Anzala; Kishor Mandaliya; Patricia Cane; James A. Berkley; Tobias F. Rinke de Wit; Carole Wallis; Susan M. Graham; Matthew A. Price; Roel A. Coutinho; Eduard J. Sanders

doi:https://doi.org/10.1089/aid.2013.0171

HIV Type 1 transmission networks among men having sex with men and heterosexuals in Kenya

Daniela Bezemer, Nuno Rodrigues Faria, Amin Hassan, Raph L. Hamers, Gaudensia Mutua, Omu Anzala, Kishor Mandaliya, Patricia Cane, James A. Berkley, Tobias F. Rinke de Wit, Carole Wallis, Susan M. Graham, Matthew A. Price, Roel A. Coutinho, Eduard J. Sanders

Research output: Contribution to journal › Article › Academic › peer-review

32 Citations (Scopus)

Abstract

We performed a molecular phylogenetic study on HIV-1 polymerase sequences of men who have sex with men (MSM) and heterosexual patient samples in Kenya to characterize any observed HIV-1 transmission networks. HIV-1 polymerase sequences were obtained from samples in Nairobi and coastal Kenya from 84 MSM, 226 other men, and 364 women from 2005 to 2010. Using Bayesian phylogenetics, we tested whether sequences clustered by sexual orientation and geographic location. In addition, we used trait diffusion analyses to identify significant epidemiological links and to quantify the number of transmissions between risk groups. Finally, we compared 84 MSM sequences with all HIV-1 sequences available online at GenBank. Significant clustering of sequences from MSM at both coastal Kenya and Nairobi was found, with evidence of HIV-1 transmission between both locations. Although a transmission pair between a coastal MSM and woman was confirmed, no significant HIV-1 transmission was evident between MSM and the comparison population for the predominant subtype A (60%). However, a weak but significant link was evident when studying all subtypes together. GenBank comparison did not reveal other important transmission links. Our data suggest infrequent intermingling of MSM and heterosexual HIV-1 epidemics in Kenya

Original language	English
Pages (from-to)	118-126
Journal	AIDS Research and Human Retroviruses
Volume	30
Issue number	2
DOIs	https://doi.org/10.1089/aid.2013.0171
Publication status	Published - 2014

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Cite this

Bezemer, D., Faria, N. R., Hassan, A., Hamers, R. L., Mutua, G., Anzala, O., Mandaliya, K., Cane, P., Berkley, J. A., Rinke de Wit, T. F., Wallis, C., Graham, S. M., Price, M. A., Coutinho, R. A., & Sanders, E. J. (2014). HIV Type 1 transmission networks among men having sex with men and heterosexuals in Kenya. AIDS Research and Human Retroviruses, 30(2), 118-126. https://doi.org/10.1089/aid.2013.0171

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title = "HIV Type 1 transmission networks among men having sex with men and heterosexuals in Kenya",

abstract = "We performed a molecular phylogenetic study on HIV-1 polymerase sequences of men who have sex with men (MSM) and heterosexual patient samples in Kenya to characterize any observed HIV-1 transmission networks. HIV-1 polymerase sequences were obtained from samples in Nairobi and coastal Kenya from 84 MSM, 226 other men, and 364 women from 2005 to 2010. Using Bayesian phylogenetics, we tested whether sequences clustered by sexual orientation and geographic location. In addition, we used trait diffusion analyses to identify significant epidemiological links and to quantify the number of transmissions between risk groups. Finally, we compared 84 MSM sequences with all HIV-1 sequences available online at GenBank. Significant clustering of sequences from MSM at both coastal Kenya and Nairobi was found, with evidence of HIV-1 transmission between both locations. Although a transmission pair between a coastal MSM and woman was confirmed, no significant HIV-1 transmission was evident between MSM and the comparison population for the predominant subtype A (60%). However, a weak but significant link was evident when studying all subtypes together. GenBank comparison did not reveal other important transmission links. Our data suggest infrequent intermingling of MSM and heterosexual HIV-1 epidemics in Kenya",

author = "Daniela Bezemer and Faria, {Nuno Rodrigues} and Amin Hassan and Hamers, {Raph L.} and Gaudensia Mutua and Omu Anzala and Kishor Mandaliya and Patricia Cane and Berkley, {James A.} and {Rinke de Wit}, {Tobias F.} and Carole Wallis and Graham, {Susan M.} and Price, {Matthew A.} and Coutinho, {Roel A.} and Sanders, {Eduard J.}",

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Bezemer, D, Faria, NR, Hassan, A, Hamers, RL, Mutua, G, Anzala, O, Mandaliya, K, Cane, P, Berkley, JA, Rinke de Wit, TF, Wallis, C, Graham, SM, Price, MA, Coutinho, RA & Sanders, EJ 2014, 'HIV Type 1 transmission networks among men having sex with men and heterosexuals in Kenya', AIDS Research and Human Retroviruses, vol. 30, no. 2, pp. 118-126. https://doi.org/10.1089/aid.2013.0171

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AU - Bezemer, Daniela

AU - Faria, Nuno Rodrigues

AU - Hassan, Amin

AU - Hamers, Raph L.

AU - Mutua, Gaudensia

AU - Anzala, Omu

AU - Mandaliya, Kishor

AU - Cane, Patricia

AU - Berkley, James A.

AU - Rinke de Wit, Tobias F.

AU - Wallis, Carole

AU - Graham, Susan M.

AU - Price, Matthew A.

AU - Coutinho, Roel A.

AU - Sanders, Eduard J.

PY - 2014

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N2 - We performed a molecular phylogenetic study on HIV-1 polymerase sequences of men who have sex with men (MSM) and heterosexual patient samples in Kenya to characterize any observed HIV-1 transmission networks. HIV-1 polymerase sequences were obtained from samples in Nairobi and coastal Kenya from 84 MSM, 226 other men, and 364 women from 2005 to 2010. Using Bayesian phylogenetics, we tested whether sequences clustered by sexual orientation and geographic location. In addition, we used trait diffusion analyses to identify significant epidemiological links and to quantify the number of transmissions between risk groups. Finally, we compared 84 MSM sequences with all HIV-1 sequences available online at GenBank. Significant clustering of sequences from MSM at both coastal Kenya and Nairobi was found, with evidence of HIV-1 transmission between both locations. Although a transmission pair between a coastal MSM and woman was confirmed, no significant HIV-1 transmission was evident between MSM and the comparison population for the predominant subtype A (60%). However, a weak but significant link was evident when studying all subtypes together. GenBank comparison did not reveal other important transmission links. Our data suggest infrequent intermingling of MSM and heterosexual HIV-1 epidemics in Kenya

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