HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry

E. K. K. Henriksen; M. K. Viken; M. Wittig; K. Holm; T. Folseraas; S. Mucha; E. Melum; J. R. Hov; K. N. Lazaridis; B. D. Juran; O. Chazouillères; M. Färkkilä; D. N. Gotthardt; P. Invernizzi; M. Carbone; G. M. Hirschfield; S. M. Rushbrook; E. Goode; C. Y. Ponsioen; R. K. Weersma; B. Eksteen; K. K. Yimam; S. C. Gordon; D. Goldberg; L. Yu; C. L. Bowlus; A. Franke; B. A. Lie; T. H. Karlsen

doi:https://doi.org/10.1111/tan.13076

HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry

E. K. K. Henriksen, M. K. Viken, M. Wittig, K. Holm, T. Folseraas, S. Mucha, E. Melum, J. R. Hov, K. N. Lazaridis, B. D. Juran, O. Chazouillères, M. Färkkilä, D. N. Gotthardt, P. Invernizzi, M. Carbone, G. M. Hirschfield, S. M. Rushbrook, E. Goode, C. Y. Ponsioen, R. K. WeersmaB. Eksteen, K. K. Yimam, S. C. Gordon, D. Goldberg, L. Yu, C. L. Bowlus, A. Franke, B. A. Lie, T. H. Karlsen

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Abstract

Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult. We aimed to evaluate whether studying populations of admixed or non-European descent could help in defining the causative HLA alleles. When assessing haplotypes carrying HLA-DRB1*13:01 (hypothesized to specifically increase the susceptibility to chronic cholangitis), we observed that every haplotype in the Scandinavian PSC population carried HLA-DQB1*06:03. In contrast, only 65% of HLA-DRB1*13:01 haplotypes in an admixed/non-European PSC population carried this allele, suggesting that further assessments of the PSC-associated haplotype HLA-DRB1*13:01DQA1*01:03-DQB1*06:03 in admixed or multi-ethnic populations could aid in identifying the causative allele

Original language	English
Pages (from-to)	228-233
Journal	HLA
Volume	90
Issue number	4
Early online date	2017
DOIs	https://doi.org/10.1111/tan.13076
Publication status	Published - 2017

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Henriksen, E. K. K., Viken, M. K., Wittig, M., Holm, K., Folseraas, T., Mucha, S., Melum, E., Hov, J. R., Lazaridis, K. N., Juran, B. D., Chazouillères, O., Färkkilä, M., Gotthardt, D. N., Invernizzi, P., Carbone, M., Hirschfield, G. M., Rushbrook, S. M., Goode, E., Ponsioen, C. Y., ... Karlsen, T. H. (2017). HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry. HLA, 90(4), 228-233. https://doi.org/10.1111/tan.13076

@article{6c5048e6bfd84e1495e4f89e7b32eaae,

title = "HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry",

abstract = "Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult. We aimed to evaluate whether studying populations of admixed or non-European descent could help in defining the causative HLA alleles. When assessing haplotypes carrying HLA-DRB1*13:01 (hypothesized to specifically increase the susceptibility to chronic cholangitis), we observed that every haplotype in the Scandinavian PSC population carried HLA-DQB1*06:03. In contrast, only 65% of HLA-DRB1*13:01 haplotypes in an admixed/non-European PSC population carried this allele, suggesting that further assessments of the PSC-associated haplotype HLA-DRB1*13:01DQA1*01:03-DQB1*06:03 in admixed or multi-ethnic populations could aid in identifying the causative allele",

author = "Henriksen, {E. K. K.} and Viken, {M. K.} and M. Wittig and K. Holm and T. Folseraas and S. Mucha and E. Melum and Hov, {J. R.} and Lazaridis, {K. N.} and Juran, {B. D.} and O. Chazouill{\`e}res and M. F{\"a}rkkil{\"a} and Gotthardt, {D. N.} and P. Invernizzi and M. Carbone and Hirschfield, {G. M.} and Rushbrook, {S. M.} and E. Goode and Ponsioen, {C. Y.} and Weersma, {R. K.} and B. Eksteen and Yimam, {K. K.} and Gordon, {S. C.} and D. Goldberg and L. Yu and Bowlus, {C. L.} and A. Franke and Lie, {B. A.} and Karlsen, {T. H.}",

year = "2017",

doi = "https://doi.org/10.1111/tan.13076",

language = "English",

volume = "90",

pages = "228--233",

journal = "HLA",

issn = "2059-2302",

publisher = "Wiley-Blackwell",

number = "4",

}

Henriksen, EKK, Viken, MK, Wittig, M, Holm, K, Folseraas, T, Mucha, S, Melum, E, Hov, JR, Lazaridis, KN, Juran, BD, Chazouillères, O, Färkkilä, M, Gotthardt, DN, Invernizzi, P, Carbone, M, Hirschfield, GM, Rushbrook, SM, Goode, E, Ponsioen, CY, Weersma, RK, Eksteen, B, Yimam, KK, Gordon, SC, Goldberg, D, Yu, L, Bowlus, CL, Franke, A, Lie, BA & Karlsen, TH 2017, 'HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry', HLA, vol. 90, no. 4, pp. 228-233. https://doi.org/10.1111/tan.13076

TY - JOUR

T1 - HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry

AU - Henriksen, E. K. K.

AU - Viken, M. K.

AU - Wittig, M.

AU - Holm, K.

AU - Folseraas, T.

AU - Mucha, S.

AU - Melum, E.

AU - Hov, J. R.

AU - Lazaridis, K. N.

AU - Juran, B. D.

AU - Chazouillères, O.

AU - Färkkilä, M.

AU - Gotthardt, D. N.

AU - Invernizzi, P.

AU - Carbone, M.

AU - Hirschfield, G. M.

AU - Rushbrook, S. M.

AU - Goode, E.

AU - Ponsioen, C. Y.

AU - Weersma, R. K.

AU - Eksteen, B.

AU - Yimam, K. K.

AU - Gordon, S. C.

AU - Goldberg, D.

AU - Yu, L.

AU - Bowlus, C. L.

AU - Franke, A.

AU - Lie, B. A.

AU - Karlsen, T. H.

PY - 2017

Y1 - 2017

N2 - Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult. We aimed to evaluate whether studying populations of admixed or non-European descent could help in defining the causative HLA alleles. When assessing haplotypes carrying HLA-DRB1*13:01 (hypothesized to specifically increase the susceptibility to chronic cholangitis), we observed that every haplotype in the Scandinavian PSC population carried HLA-DQB1*06:03. In contrast, only 65% of HLA-DRB1*13:01 haplotypes in an admixed/non-European PSC population carried this allele, suggesting that further assessments of the PSC-associated haplotype HLA-DRB1*13:01DQA1*01:03-DQB1*06:03 in admixed or multi-ethnic populations could aid in identifying the causative allele

AB - Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult. We aimed to evaluate whether studying populations of admixed or non-European descent could help in defining the causative HLA alleles. When assessing haplotypes carrying HLA-DRB1*13:01 (hypothesized to specifically increase the susceptibility to chronic cholangitis), we observed that every haplotype in the Scandinavian PSC population carried HLA-DQB1*06:03. In contrast, only 65% of HLA-DRB1*13:01 haplotypes in an admixed/non-European PSC population carried this allele, suggesting that further assessments of the PSC-associated haplotype HLA-DRB1*13:01DQA1*01:03-DQB1*06:03 in admixed or multi-ethnic populations could aid in identifying the causative allele

U2 - https://doi.org/10.1111/tan.13076

DO - https://doi.org/10.1111/tan.13076

M3 - Article

C2 - 28695657

SN - 2059-2302

VL - 90

SP - 228

EP - 233

JO - HLA

JF - HLA

IS - 4

ER -