Holmium-166 poly(L-lactic acid) microsphere radioembolisation of the liver: technical aspects studied in a large animal model

M. A. D. Vente; T. C. de Wit; M. A. A. J. van den Bosch; W. Bult; P. R. Seevinck; B. A. Zonnenberg; H. W. A. M. de Jong; G. C. Krijger; C. J. G. Bakker; A. D. van het Schip; J. F. W. Nijsen

doi:https://doi.org/10.1007/s00330-009-1613-1

Holmium-166 poly(L-lactic acid) microsphere radioembolisation of the liver: technical aspects studied in a large animal model

M. A. D. Vente, T. C. de Wit, M. A. A. J. van den Bosch, W. Bult, P. R. Seevinck, B. A. Zonnenberg, H. W. A. M. de Jong, G. C. Krijger, C. J. G. Bakker, A. D. van het Schip, J. F. W. Nijsen

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Abstract

OBJECTIVE: To assess the accuracy of a scout dose of holmium-166 poly(L-lactic acid) microspheres ((166)Ho-PLLA-MS) in predicting the distribution of a treatment dose of (166)Ho-PLLA-MS, using single photon emission tomography (SPECT). METHODS: A scout dose (60 mg) was injected into the hepatic artery of five pigs and SPECT acquired. Subsequently, a 'treatment dose' was administered (540 mg) and SPECT, computed tomography (CT) and magnetic resonance imaging (MRI) of the total dose performed. The two SPECT images of each animal were compared. To validate quantitative SPECT an ex vivo liver was instilled with (166)Ho-PLLA-MS and SPECT acquired. The liver was cut into slices and planar images were acquired, which were registered to the SPECT image. RESULTS: Qualitatively, the scout dose and total dose images were similar, except in one animal because of catheter displacement. Quantitative analysis, feasible in two animals, tended to confirm this similarity (r(2) = 0.34); in the other animal the relation was significantly better (r(2) = 0.66). The relation between the SPECT and planar images acquired from the ex vivo liver was strong (r(2) = 0.90). CONCLUSION: In the porcine model a scout dose of (166)Ho-PLLA-MS can accurately predict the biodistribution of a treatment dose. Quantitative (166)Ho SPECT was validated for clinical application

Original language	English
Pages (from-to)	862-869
Journal	European Radiology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1007/s00330-009-1613-1
Publication status	Published - 2010

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https://doi.org/10.1007/s00330-009-1613-1

Cite this

Vente, M. A. D., de Wit, T. C., van den Bosch, M. A. A. J., Bult, W., Seevinck, P. R., Zonnenberg, B. A., de Jong, H. W. A. M., Krijger, G. C., Bakker, C. J. G., van het Schip, A. D., & Nijsen, J. F. W. (2010). Holmium-166 poly(L-lactic acid) microsphere radioembolisation of the liver: technical aspects studied in a large animal model. European Radiology, 20(4), 862-869. https://doi.org/10.1007/s00330-009-1613-1

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title = "Holmium-166 poly(L-lactic acid) microsphere radioembolisation of the liver: technical aspects studied in a large animal model",

abstract = "OBJECTIVE: To assess the accuracy of a scout dose of holmium-166 poly(L-lactic acid) microspheres ((166)Ho-PLLA-MS) in predicting the distribution of a treatment dose of (166)Ho-PLLA-MS, using single photon emission tomography (SPECT). METHODS: A scout dose (60 mg) was injected into the hepatic artery of five pigs and SPECT acquired. Subsequently, a 'treatment dose' was administered (540 mg) and SPECT, computed tomography (CT) and magnetic resonance imaging (MRI) of the total dose performed. The two SPECT images of each animal were compared. To validate quantitative SPECT an ex vivo liver was instilled with (166)Ho-PLLA-MS and SPECT acquired. The liver was cut into slices and planar images were acquired, which were registered to the SPECT image. RESULTS: Qualitatively, the scout dose and total dose images were similar, except in one animal because of catheter displacement. Quantitative analysis, feasible in two animals, tended to confirm this similarity (r(2) = 0.34); in the other animal the relation was significantly better (r(2) = 0.66). The relation between the SPECT and planar images acquired from the ex vivo liver was strong (r(2) = 0.90). CONCLUSION: In the porcine model a scout dose of (166)Ho-PLLA-MS can accurately predict the biodistribution of a treatment dose. Quantitative (166)Ho SPECT was validated for clinical application",

author = "Vente, {M. A. D.} and {de Wit}, {T. C.} and {van den Bosch}, {M. A. A. J.} and W. Bult and Seevinck, {P. R.} and Zonnenberg, {B. A.} and {de Jong}, {H. W. A. M.} and Krijger, {G. C.} and Bakker, {C. J. G.} and {van het Schip}, {A. D.} and Nijsen, {J. F. W.}",

year = "2010",

doi = "https://doi.org/10.1007/s00330-009-1613-1",

language = "English",

volume = "20",

pages = "862--869",

journal = "European Radiology",

issn = "0938-7994",

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Vente, MAD, de Wit, TC, van den Bosch, MAAJ, Bult, W, Seevinck, PR, Zonnenberg, BA, de Jong, HWAM, Krijger, GC, Bakker, CJG, van het Schip, AD & Nijsen, JFW 2010, 'Holmium-166 poly(L-lactic acid) microsphere radioembolisation of the liver: technical aspects studied in a large animal model', European Radiology, vol. 20, no. 4, pp. 862-869. https://doi.org/10.1007/s00330-009-1613-1

TY - JOUR

T1 - Holmium-166 poly(L-lactic acid) microsphere radioembolisation of the liver: technical aspects studied in a large animal model

AU - Vente, M. A. D.

AU - de Wit, T. C.

AU - van den Bosch, M. A. A. J.

AU - Bult, W.

AU - Seevinck, P. R.

AU - Zonnenberg, B. A.

AU - de Jong, H. W. A. M.

AU - Krijger, G. C.

AU - Bakker, C. J. G.

AU - van het Schip, A. D.

AU - Nijsen, J. F. W.

PY - 2010

Y1 - 2010

N2 - OBJECTIVE: To assess the accuracy of a scout dose of holmium-166 poly(L-lactic acid) microspheres ((166)Ho-PLLA-MS) in predicting the distribution of a treatment dose of (166)Ho-PLLA-MS, using single photon emission tomography (SPECT). METHODS: A scout dose (60 mg) was injected into the hepatic artery of five pigs and SPECT acquired. Subsequently, a 'treatment dose' was administered (540 mg) and SPECT, computed tomography (CT) and magnetic resonance imaging (MRI) of the total dose performed. The two SPECT images of each animal were compared. To validate quantitative SPECT an ex vivo liver was instilled with (166)Ho-PLLA-MS and SPECT acquired. The liver was cut into slices and planar images were acquired, which were registered to the SPECT image. RESULTS: Qualitatively, the scout dose and total dose images were similar, except in one animal because of catheter displacement. Quantitative analysis, feasible in two animals, tended to confirm this similarity (r(2) = 0.34); in the other animal the relation was significantly better (r(2) = 0.66). The relation between the SPECT and planar images acquired from the ex vivo liver was strong (r(2) = 0.90). CONCLUSION: In the porcine model a scout dose of (166)Ho-PLLA-MS can accurately predict the biodistribution of a treatment dose. Quantitative (166)Ho SPECT was validated for clinical application

AB - OBJECTIVE: To assess the accuracy of a scout dose of holmium-166 poly(L-lactic acid) microspheres ((166)Ho-PLLA-MS) in predicting the distribution of a treatment dose of (166)Ho-PLLA-MS, using single photon emission tomography (SPECT). METHODS: A scout dose (60 mg) was injected into the hepatic artery of five pigs and SPECT acquired. Subsequently, a 'treatment dose' was administered (540 mg) and SPECT, computed tomography (CT) and magnetic resonance imaging (MRI) of the total dose performed. The two SPECT images of each animal were compared. To validate quantitative SPECT an ex vivo liver was instilled with (166)Ho-PLLA-MS and SPECT acquired. The liver was cut into slices and planar images were acquired, which were registered to the SPECT image. RESULTS: Qualitatively, the scout dose and total dose images were similar, except in one animal because of catheter displacement. Quantitative analysis, feasible in two animals, tended to confirm this similarity (r(2) = 0.34); in the other animal the relation was significantly better (r(2) = 0.66). The relation between the SPECT and planar images acquired from the ex vivo liver was strong (r(2) = 0.90). CONCLUSION: In the porcine model a scout dose of (166)Ho-PLLA-MS can accurately predict the biodistribution of a treatment dose. Quantitative (166)Ho SPECT was validated for clinical application

U2 - https://doi.org/10.1007/s00330-009-1613-1

DO - https://doi.org/10.1007/s00330-009-1613-1

M3 - Article

C2 - 19789880

SN - 0938-7994

VL - 20

SP - 862

EP - 869

JO - European Radiology

JF - European Radiology

IS - 4

ER -