Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis

Sebastiaan Weijer; Jaklien C. Leemans; Sandrine Florquin; Takao Shimizu; Satoshi Ishii; Tom van der Poll

doi:https://doi.org/10.1046/j.1365-2567.2003.01688.x

Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis

Sebastiaan Weijer, Jaklien C. Leemans, Sandrine Florquin, Takao Shimizu, Satoshi Ishii, Tom van der Poll

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

Platelet-activating factor (PAF) is a phospholipid with potent, diverse actions, which has been implicated as an important mediator in host defence against several intracellular pathogens. To determine the role of PAF in host defence in pulmonary tuberculosis, PAF receptor-deficient (PAFR-/-) and wild-type (PAFR+/+) mice were infected intranasally with a virulent strain of Mycobacterium tuberculosis. Mycobacterial outgrowth in lungs and liver did not differ significantly between PAFR-/- and PAFR+/+ mice at 2 or 6 weeks postinfection. After 28 weeks, 86% of PAFR-/- mice and 79% of PAFR+/+ mice had died (non-significant). In addition, both mouse strains were indistinguishable with respect to histopathology, the recruitment and activation of lymphocytes, and cytokine concentrations in the lung. These data suggest that PAF is not involved in the protective immune response to tuberculosis

Original language	English
Pages (from-to)	552-556
Journal	Immunology
Volume	109
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2567.2003.01688.x
Publication status	Published - 2003

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https://doi.org/10.1046/j.1365-2567.2003.01688.x

Cite this

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title = "Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis",

abstract = "Platelet-activating factor (PAF) is a phospholipid with potent, diverse actions, which has been implicated as an important mediator in host defence against several intracellular pathogens. To determine the role of PAF in host defence in pulmonary tuberculosis, PAF receptor-deficient (PAFR-/-) and wild-type (PAFR+/+) mice were infected intranasally with a virulent strain of Mycobacterium tuberculosis. Mycobacterial outgrowth in lungs and liver did not differ significantly between PAFR-/- and PAFR+/+ mice at 2 or 6 weeks postinfection. After 28 weeks, 86% of PAFR-/- mice and 79% of PAFR+/+ mice had died (non-significant). In addition, both mouse strains were indistinguishable with respect to histopathology, the recruitment and activation of lymphocytes, and cytokine concentrations in the lung. These data suggest that PAF is not involved in the protective immune response to tuberculosis",

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T1 - Host response of platelet-activating factor receptor-deficient mice during pulmonary tuberculosis

AU - Weijer, Sebastiaan

AU - Leemans, Jaklien C.

AU - Florquin, Sandrine

AU - Shimizu, Takao

AU - Ishii, Satoshi

AU - van der Poll, Tom

PY - 2003

Y1 - 2003

N2 - Platelet-activating factor (PAF) is a phospholipid with potent, diverse actions, which has been implicated as an important mediator in host defence against several intracellular pathogens. To determine the role of PAF in host defence in pulmonary tuberculosis, PAF receptor-deficient (PAFR-/-) and wild-type (PAFR+/+) mice were infected intranasally with a virulent strain of Mycobacterium tuberculosis. Mycobacterial outgrowth in lungs and liver did not differ significantly between PAFR-/- and PAFR+/+ mice at 2 or 6 weeks postinfection. After 28 weeks, 86% of PAFR-/- mice and 79% of PAFR+/+ mice had died (non-significant). In addition, both mouse strains were indistinguishable with respect to histopathology, the recruitment and activation of lymphocytes, and cytokine concentrations in the lung. These data suggest that PAF is not involved in the protective immune response to tuberculosis

AB - Platelet-activating factor (PAF) is a phospholipid with potent, diverse actions, which has been implicated as an important mediator in host defence against several intracellular pathogens. To determine the role of PAF in host defence in pulmonary tuberculosis, PAF receptor-deficient (PAFR-/-) and wild-type (PAFR+/+) mice were infected intranasally with a virulent strain of Mycobacterium tuberculosis. Mycobacterial outgrowth in lungs and liver did not differ significantly between PAFR-/- and PAFR+/+ mice at 2 or 6 weeks postinfection. After 28 weeks, 86% of PAFR-/- mice and 79% of PAFR+/+ mice had died (non-significant). In addition, both mouse strains were indistinguishable with respect to histopathology, the recruitment and activation of lymphocytes, and cytokine concentrations in the lung. These data suggest that PAF is not involved in the protective immune response to tuberculosis

U2 - https://doi.org/10.1046/j.1365-2567.2003.01688.x

DO - https://doi.org/10.1046/j.1365-2567.2003.01688.x

M3 - Article

C2 - 12871222

SN - 0019-2805

VL - 109

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JO - Immunology

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