TY - JOUR
T1 - How Do Antegrade Enemas Work? Colonic Motility in Response to Administration of Normal Saline Solution Into the Proximal Colon
AU - Gomez, Roberto
AU - Mousa, Hayat
AU - Liem, Olivia
AU - Hayes, John
AU - Di Lorenzo, Carlo
PY - 2010
Y1 - 2010
N2 - Objective: The aim of the study was to evaluate the colonic motor response to the administration of normal saline into the proximal colon. Patients and Methods: Pediatric patients undergoing colonic manometry received a saline infusion (10-20 mL/kg) in 10 minutes through the central lumen of a catheter placed into the proximal colon. We compared the number of high-amplitude propagated contractions (HAPCs), motility index, frequency and propagation of other phasic contractions in the 20 minutes before and after normal saline infusion, meal ingestion, and bisacodyl administration. Results: Thirteen patients, mean age 9.4 +/- 5.8 years, received the saline infusion (3 in the cecum, 8 in the hepatic flexure, and 2 in the transverse colon). In the first 20 minutes after saline infusion, the number of contractions (P = 0.005), distance of propagation of contractions (P = 0.007), frequency of contractions (P = 0.009), and motility index (P = 0.003) were significantly higher compared with baseline. Mean amplitude and number of HAPCs were not significantly different from baseline. Motility parameters after saline and after ingestion of a meal did not differ. All of the measured motility variables significantly increased after bisacodyl stimulation. Bisacodyl increased the motility index and HAPCs more than either saline infusion (P = 0.002) or meal intake (P <0.001). Conclusions: Infusion of saline into the proximal colon is associated with an increase in colonic motility; however, at the volume and rate used in the present study it does not consistently stimulate HAPCs
AB - Objective: The aim of the study was to evaluate the colonic motor response to the administration of normal saline into the proximal colon. Patients and Methods: Pediatric patients undergoing colonic manometry received a saline infusion (10-20 mL/kg) in 10 minutes through the central lumen of a catheter placed into the proximal colon. We compared the number of high-amplitude propagated contractions (HAPCs), motility index, frequency and propagation of other phasic contractions in the 20 minutes before and after normal saline infusion, meal ingestion, and bisacodyl administration. Results: Thirteen patients, mean age 9.4 +/- 5.8 years, received the saline infusion (3 in the cecum, 8 in the hepatic flexure, and 2 in the transverse colon). In the first 20 minutes after saline infusion, the number of contractions (P = 0.005), distance of propagation of contractions (P = 0.007), frequency of contractions (P = 0.009), and motility index (P = 0.003) were significantly higher compared with baseline. Mean amplitude and number of HAPCs were not significantly different from baseline. Motility parameters after saline and after ingestion of a meal did not differ. All of the measured motility variables significantly increased after bisacodyl stimulation. Bisacodyl increased the motility index and HAPCs more than either saline infusion (P = 0.002) or meal intake (P <0.001). Conclusions: Infusion of saline into the proximal colon is associated with an increase in colonic motility; however, at the volume and rate used in the present study it does not consistently stimulate HAPCs
U2 - https://doi.org/10.1097/MPG.0b013e3181e75d18
DO - https://doi.org/10.1097/MPG.0b013e3181e75d18
M3 - Article
C2 - 20890219
SN - 0277-2116
VL - 51
SP - 741
EP - 746
JO - Journal of pediatric gastroenterology and nutrition
JF - Journal of pediatric gastroenterology and nutrition
IS - 6
ER -