TY - JOUR
T1 - How do mycobacteria activate CD8(+) T cells?
AU - Weerdenburg, Eveline M.
AU - Peters, Peter J.
AU - van der Wel, Nicole N.
PY - 2010
Y1 - 2010
N2 - CD8(+) T cells are activated upon presentation of antigens from the cytosol. Therefore, it was unclear how pathogenic mycobacteria could prime this type of lymphocyte, given that these microbes were thought to remain in phagosomes and, hence, be shielded from the host cytosol. Recently, it was shown that some mycobacteria can enter the cytosol through translocation from phagolysosomes, providing a direct mechanism for CD8(+) T cell priming. However, this mechanism might not apply to other mycobacteria, which do not appear to be able to enter the cytosol. Here, we discuss the different hypotheses to explain the induction of CD8(+) T cell responses in mycobacterial infections
AB - CD8(+) T cells are activated upon presentation of antigens from the cytosol. Therefore, it was unclear how pathogenic mycobacteria could prime this type of lymphocyte, given that these microbes were thought to remain in phagosomes and, hence, be shielded from the host cytosol. Recently, it was shown that some mycobacteria can enter the cytosol through translocation from phagolysosomes, providing a direct mechanism for CD8(+) T cell priming. However, this mechanism might not apply to other mycobacteria, which do not appear to be able to enter the cytosol. Here, we discuss the different hypotheses to explain the induction of CD8(+) T cell responses in mycobacterial infections
U2 - https://doi.org/10.1016/j.tim.2009.10.004
DO - https://doi.org/10.1016/j.tim.2009.10.004
M3 - Review article
C2 - 19962899
SN - 0966-842X
VL - 18
SP - 1
EP - 10
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 1
ER -