How should we manage a patient with invasive mucoromycosis who develops life-threatening reaction to amphotericin B? Report of two cases and literature review

Fereshte Sheybani; Hamid Reza Naderi; Mohammad Reza Sarvghad; Mohammad Javad Ghabouli; Mahnaz Arian

doi:https://doi.org/10.1016/j.mmcr.2015.03.003

How should we manage a patient with invasive mucoromycosis who develops life-threatening reaction to amphotericin B? Report of two cases and literature review

Fereshte Sheybani, Hamid Reza Naderi, Mohammad Reza Sarvghad, Mohammad Javad Ghabouli, Mahnaz Arian

Doctoral School

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

Abstract This report presents two cases of invasive rhino-orbital mucormycosis who had life-threatening reactions to amphotericin B. Both cases were treated with a combination of posaconazole-caspofungin favorably with no evidence of recurrence upon long-term follow-up. To our knowledge, this is the first report of successful treatment of invasive mucormycosis with azole-echinocandin combination. It may suggest that caspofungin exerts additional or even synergistic antimucoral effects to posaconazole.

Original language	English
Article number	146
Pages (from-to)	29-31
Number of pages	3
Journal	MEDICAL MYCOLOGY CASE REPORTS
Volume	8
DOIs	https://doi.org/10.1016/j.mmcr.2015.03.003
Publication status	Published - Jun 2015

Keywords

Azole-echinocandin
Caspofungin
Mucormycosis
Posaconazole

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https://doi.org/10.1016/j.mmcr.2015.03.003

Cite this

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title = "How should we manage a patient with invasive mucoromycosis who develops life-threatening reaction to amphotericin B? Report of two cases and literature review",

abstract = "Abstract This report presents two cases of invasive rhino-orbital mucormycosis who had life-threatening reactions to amphotericin B. Both cases were treated with a combination of posaconazole-caspofungin favorably with no evidence of recurrence upon long-term follow-up. To our knowledge, this is the first report of successful treatment of invasive mucormycosis with azole-echinocandin combination. It may suggest that caspofungin exerts additional or even synergistic antimucoral effects to posaconazole.",

keywords = "Azole-echinocandin, Caspofungin, Mucormycosis, Posaconazole",

author = "Fereshte Sheybani and Naderi, {Hamid Reza} and Sarvghad, {Mohammad Reza} and Ghabouli, {Mohammad Javad} and Mahnaz Arian",

year = "2015",

month = jun,

doi = "https://doi.org/10.1016/j.mmcr.2015.03.003",

language = "English",

volume = "8",

pages = "29--31",

journal = "MEDICAL MYCOLOGY CASE REPORTS",

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publisher = "Elsevier BV",

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How should we manage a patient with invasive mucoromycosis who develops life-threatening reaction to amphotericin B? Report of two cases and literature review. / Sheybani, Fereshte; Naderi, Hamid Reza; Sarvghad, Mohammad Reza et al.
In: MEDICAL MYCOLOGY CASE REPORTS, Vol. 8, 146, 06.2015, p. 29-31.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - How should we manage a patient with invasive mucoromycosis who develops life-threatening reaction to amphotericin B? Report of two cases and literature review

AU - Sheybani, Fereshte

AU - Naderi, Hamid Reza

AU - Sarvghad, Mohammad Reza

AU - Ghabouli, Mohammad Javad

AU - Arian, Mahnaz

PY - 2015/6

Y1 - 2015/6

N2 - Abstract This report presents two cases of invasive rhino-orbital mucormycosis who had life-threatening reactions to amphotericin B. Both cases were treated with a combination of posaconazole-caspofungin favorably with no evidence of recurrence upon long-term follow-up. To our knowledge, this is the first report of successful treatment of invasive mucormycosis with azole-echinocandin combination. It may suggest that caspofungin exerts additional or even synergistic antimucoral effects to posaconazole.

AB - Abstract This report presents two cases of invasive rhino-orbital mucormycosis who had life-threatening reactions to amphotericin B. Both cases were treated with a combination of posaconazole-caspofungin favorably with no evidence of recurrence upon long-term follow-up. To our knowledge, this is the first report of successful treatment of invasive mucormycosis with azole-echinocandin combination. It may suggest that caspofungin exerts additional or even synergistic antimucoral effects to posaconazole.

KW - Azole-echinocandin

KW - Caspofungin

KW - Mucormycosis

KW - Posaconazole

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JO - MEDICAL MYCOLOGY CASE REPORTS

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ER -

How should we manage a patient with invasive mucoromycosis who develops life-threatening reaction to amphotericin B? Report of two cases and literature review

Abstract

Keywords

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