Abstract
Coagulopathy is a severe and frequent complication in critically ill patients, for which the pathogenesis and presentation may be variable depending on the underlying disease. Based on the dominant clinical phenotype, the current review differentiates between hemorrhagic coagulopathies, characterized by a hypocoagulable and hyperfibrinolysis state, and thrombotic coagulopathies with a systemic prothrombotic and antifibrinolytic phenotype. We discuss the differences in pathogenesis and treatment of the common coagulopathies.
Original language | English |
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Pages (from-to) | 273-290 |
Number of pages | 18 |
Journal | Intensive care medicine |
Volume | 49 |
Issue number | 3 |
Early online date | 2023 |
DOIs | |
Publication status | Published - Mar 2023 |
Keywords
- Coagulopathy
- Critical care
- Disseminated intravascular coagulation
- Hematological disease
- Sepsis
- Trauma