TY - JOUR
T1 - Human basal cortisol levels are increased in hospital compared to home setting
AU - Scheer, Frank A. J. L.
AU - van Paassen, Barbara
AU - van Montfrans, Gert A.
AU - Fliers, Eric
AU - van Someren, Eus J. W.
AU - van Heerikhuize, Joop J.
AU - Buijs, Ruud M.
PY - 2002
Y1 - 2002
N2 - The impact of study-environment on experimental outcome is mostly not realized and certainly not demonstrated. In the present study, a comparison was made between free salivary cortisol levels in healthy young men in a carefully controlled hospital setting versus a home setting. Cortisol levels during rest were increased in hospital compared to home environment: 2-fold at awakening, 3-fold at the morning peak, and 5-fold late in the evening. Early morning light increased cortisol concentrations only in the home setting, while this effect was absent in the hospital setting. The data of the present study show that study-environment has a major impact on basal hypothalamo-pituitary-adrenal (HPA)-axis activity, which is of particular relevance in future studies in which small changes in HPA-axis activity are subject of study. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved
AB - The impact of study-environment on experimental outcome is mostly not realized and certainly not demonstrated. In the present study, a comparison was made between free salivary cortisol levels in healthy young men in a carefully controlled hospital setting versus a home setting. Cortisol levels during rest were increased in hospital compared to home environment: 2-fold at awakening, 3-fold at the morning peak, and 5-fold late in the evening. Early morning light increased cortisol concentrations only in the home setting, while this effect was absent in the hospital setting. The data of the present study show that study-environment has a major impact on basal hypothalamo-pituitary-adrenal (HPA)-axis activity, which is of particular relevance in future studies in which small changes in HPA-axis activity are subject of study. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved
U2 - https://doi.org/10.1016/S0304-3940(02)00988-6
DO - https://doi.org/10.1016/S0304-3940(02)00988-6
M3 - Article
C2 - 12419485
SN - 0304-3940
VL - 333
SP - 79
EP - 82
JO - Neuroscience letters
JF - Neuroscience letters
IS - 2
ER -