Human coronavirus NL63, France

Astrid Vabret; Thomas Mourez; Julia Dina; Lia van der Hoek; Stéphanie Gouarin; Joëlle Petitjean; Jacques Brouard; François Freymuth; S. Gourarin

doi:https://doi.org/10.3201/eid1108.050110

Human coronavirus NL63, France

Astrid Vabret, Thomas Mourez, Julia Dina, Lia van der Hoek, Stéphanie Gouarin, Joëlle Petitjean, Jacques Brouard, François Freymuth, S. Gourarin

Research output: Contribution to journal › Article › Academic › peer-review

207 Citations (Scopus)

Abstract

The human coronavirus NL63 (HCoV-NL63) was first identified in The Netherlands, and its circulation in France has not been investigated. We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 respiratory specimens for HCoV-NL63. Of the 300 samples, 28 (9.3%) were positive for HCoV-NL63. The highest prevalence was found in February (18%). The main symptoms were fever (61%), rhinitis (39%), bronchiolitis (39%), digestive problems (33%), otitis (28%), pharyngitis (22%), and conjunctivitis (17%). A fragment of the spike protein gene was sequenced to determine the variety of circulating HCoV-NL63. Phylogenetic analysis indicated that strains with different genetic markers cocirculate in France

Original language	English
Pages (from-to)	1225-1229
Journal	Emerging infectious diseases
Volume	11
Issue number	8
DOIs	https://doi.org/10.3201/eid1108.050110
Publication status	Published - 2005

Keywords

AMC wi-buiten

Access to Document

https://doi.org/10.3201/eid1108.050110

https://pure.uva.nl/ws/files/3917365/45469_206510y.pdf

Cite this

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title = "Human coronavirus NL63, France",

abstract = "The human coronavirus NL63 (HCoV-NL63) was first identified in The Netherlands, and its circulation in France has not been investigated. We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 respiratory specimens for HCoV-NL63. Of the 300 samples, 28 (9.3%) were positive for HCoV-NL63. The highest prevalence was found in February (18%). The main symptoms were fever (61%), rhinitis (39%), bronchiolitis (39%), digestive problems (33%), otitis (28%), pharyngitis (22%), and conjunctivitis (17%). A fragment of the spike protein gene was sequenced to determine the variety of circulating HCoV-NL63. Phylogenetic analysis indicated that strains with different genetic markers cocirculate in France",

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T1 - Human coronavirus NL63, France

AU - Vabret, Astrid

AU - Mourez, Thomas

AU - Dina, Julia

AU - van der Hoek, Lia

AU - Gouarin, Stéphanie

AU - Petitjean, Joëlle

AU - Brouard, Jacques

AU - Freymuth, François

AU - Gourarin, S.

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