Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease

C. Shimizu; H. Shike; S.C. Baker; F. Garcia; L. van der Hoek; T.W. Kuijpers; S.L. Reed; A.H. Rowley; S.T. Shulman; H.K.B. Talbot; J.V. Williams; J.C. Burns

doi:https://doi.org/10.1086/497170

Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease

C. Shimizu, H. Shike, S.C. Baker, F. Garcia, L. van der Hoek, T.W. Kuijpers, S.L. Reed, A.H. Rowley, S.T. Shulman, H.K.B. Talbot, J.V. Williams, J.C. Burns

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Abstract

Kawasaki disease (KD) is a self-limited, systemic vasculitis of children for which an infectious trigger is suspected. Recently, an association between KD and human coronavirus ( HCoV) - New Haven (NH) was reported, on the basis of polymerase chain reaction (PCR) with primers that also amplified HCoV-NL63. We investigated the possible association between these HCoVs in the respiratory tract and KD by reverse-transcriptase (RT) PCR and viral culture in a geographically and ethnically diverse population. Only 1 (2%) of 48 patients with acute KD was positive by RT-PCR for HCoV-NL63/NH in a nasopharyngeal swab. These data do not support an association between these HCoVs and KD

Original language	Undefined/Unknown
Pages (from-to)	1767-1771
Journal	The Journal of Infectious Diseases
Volume	192
Issue number	10
DOIs	https://doi.org/10.1086/497170
Publication status	Published - 2005

Keywords

AMC wi-buiten

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https://doi.org/10.1086/497170

https://pure.uva.nl/ws/files/3837188/45715_207573y.pdf

Cite this

Shimizu, C., Shike, H., Baker, S. C., Garcia, F., van der Hoek, L., Kuijpers, T. W., Reed, S. L., Rowley, A. H., Shulman, S. T., Talbot, H. K. B., Williams, J. V., & Burns, J. C. (2005). Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease. The Journal of Infectious Diseases, 192(10), 1767-1771. https://doi.org/10.1086/497170

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abstract = "Kawasaki disease (KD) is a self-limited, systemic vasculitis of children for which an infectious trigger is suspected. Recently, an association between KD and human coronavirus ( HCoV) - New Haven (NH) was reported, on the basis of polymerase chain reaction (PCR) with primers that also amplified HCoV-NL63. We investigated the possible association between these HCoVs in the respiratory tract and KD by reverse-transcriptase (RT) PCR and viral culture in a geographically and ethnically diverse population. Only 1 (2%) of 48 patients with acute KD was positive by RT-PCR for HCoV-NL63/NH in a nasopharyngeal swab. These data do not support an association between these HCoVs and KD",

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T1 - Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease

AU - Shimizu, C.

AU - Shike, H.

AU - Baker, S.C.

AU - Garcia, F.

AU - van der Hoek, L.

AU - Kuijpers, T.W.

AU - Reed, S.L.

AU - Rowley, A.H.

AU - Shulman, S.T.

AU - Talbot, H.K.B.

AU - Williams, J.V.

AU - Burns, J.C.

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AB - Kawasaki disease (KD) is a self-limited, systemic vasculitis of children for which an infectious trigger is suspected. Recently, an association between KD and human coronavirus ( HCoV) - New Haven (NH) was reported, on the basis of polymerase chain reaction (PCR) with primers that also amplified HCoV-NL63. We investigated the possible association between these HCoVs in the respiratory tract and KD by reverse-transcriptase (RT) PCR and viral culture in a geographically and ethnically diverse population. Only 1 (2%) of 48 patients with acute KD was positive by RT-PCR for HCoV-NL63/NH in a nasopharyngeal swab. These data do not support an association between these HCoVs and KD

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