TY - JOUR
T1 - Human embryonic and fetal biobanking
T2 - Establishing the Dutch Fetal Biobank and a framework for standardization
AU - Dawood, Yousif
AU - Buijtendijk, Marieke F. J.
AU - Bohly, Doriane
AU - Gunst, Quinn D.
AU - Docter, Daniel
AU - Pajkrt, Eva
AU - Oostra, Roelof-Jan
AU - Hennekam, Raoul C.
AU - van den Hoff, Maurice J. B.
AU - de Bakker, Bernadette S.
PY - 2023/12/18
Y1 - 2023/12/18
N2 - Recent studies of human embryos and fetuses have advanced our understanding not only of basic biology but also of health and disease, through a combination of detailed three-dimensional (3D) morphology and processes such as gene expression, cellular decision-making and differentiation, and epigenetics during the various phases of human development and growth. Large-scale research initiatives focusing on these topics have been initiated during the last decade, all of which depend on biobanks that provide high-quality images of human embryonic and fetal morphology, as well as on high-quality collections of tissue samples that are obtained and stored appropriately. In this perspective, we describe our experience in establishing the Dutch Fetal Biobank to present the framework and workflow of the biobank, provide a brief discussion of the main legal and ethical aspects involved in establishing a pre-natal tissue bank, and present the preliminary data on the first 329 donated specimens.
AB - Recent studies of human embryos and fetuses have advanced our understanding not only of basic biology but also of health and disease, through a combination of detailed three-dimensional (3D) morphology and processes such as gene expression, cellular decision-making and differentiation, and epigenetics during the various phases of human development and growth. Large-scale research initiatives focusing on these topics have been initiated during the last decade, all of which depend on biobanks that provide high-quality images of human embryonic and fetal morphology, as well as on high-quality collections of tissue samples that are obtained and stored appropriately. In this perspective, we describe our experience in establishing the Dutch Fetal Biobank to present the framework and workflow of the biobank, provide a brief discussion of the main legal and ethical aspects involved in establishing a pre-natal tissue bank, and present the preliminary data on the first 329 donated specimens.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85179764315&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/38113849
U2 - 10.1016/j.devcel.2023.11.019
DO - 10.1016/j.devcel.2023.11.019
M3 - Review article
C2 - 38113849
SN - 1534-5807
VL - 58
SP - 2826
EP - 2835
JO - Developmental Cell
JF - Developmental Cell
IS - 24
ER -