Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein

W Wang; L R Meadows; J M den Haan; N E Sherman; Y Chen; E Blokland; J Shabanowitz; A I Agulnik; R C Hendrickson; C E Bishop

Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein

W Wang, L R Meadows, J M den Haan, N E Sherman, Y Chen, E Blokland, J Shabanowitz, A I Agulnik, R C Hendrickson, C E Bishop

Research output: Contribution to journal › Article › Academic › peer-review

336 Citations (Scopus)

Abstract

H-Y is a transplantation antigen that can lead to rejection of male organ and bone marrow grafts by female recipients, even if the donor and recipient match at the major histocompatibility locus of humans, the HLA (human leukocyte antigen) locus. However, the origin and function of H-Y antigens has eluded researchers for 40 years. One human H-Y antigen presented by HLA-B7 was identified as an 11-residue peptide derived from SMCY, an evolutionarily conserved protein encoded on the Y chromosome. The protein from the homologous gene on the X chromosome, SMCX, differs by two amino acid residues in the same region. The identification of H-Y may aid in transplantation prognosis, prenatal diagnosis, and fertilization strategies.

Original language	English
Pages (from-to)	1588-90
Number of pages	3
Journal	Science
Volume	269
Issue number	5230
Publication status	Published - 15 Sept 1995

Keywords

Amino Acid Sequence
B-Lymphocytes
Cell Line
Chromatography, High Pressure Liquid
H-Y Antigen/chemistry
HLA-B7 Antigen/immunology
Histone Demethylases
Histone-Lysine N-Methyltransferase
Humans
Male
Mass Spectrometry/methods
Minor Histocompatibility Antigens
Molecular Sequence Data
Molecular Weight
Oxidoreductases, N-Demethylating
Proteins/chemistry
T-Lymphocytes, Cytotoxic/immunology
X Chromosome
Y Chromosome

Cite this

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title = "Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein",

abstract = "H-Y is a transplantation antigen that can lead to rejection of male organ and bone marrow grafts by female recipients, even if the donor and recipient match at the major histocompatibility locus of humans, the HLA (human leukocyte antigen) locus. However, the origin and function of H-Y antigens has eluded researchers for 40 years. One human H-Y antigen presented by HLA-B7 was identified as an 11-residue peptide derived from SMCY, an evolutionarily conserved protein encoded on the Y chromosome. The protein from the homologous gene on the X chromosome, SMCX, differs by two amino acid residues in the same region. The identification of H-Y may aid in transplantation prognosis, prenatal diagnosis, and fertilization strategies.",

keywords = "Amino Acid Sequence, B-Lymphocytes, Cell Line, Chromatography, High Pressure Liquid, H-Y Antigen/chemistry, HLA-B7 Antigen/immunology, Histone Demethylases, Histone-Lysine N-Methyltransferase, Humans, Male, Mass Spectrometry/methods, Minor Histocompatibility Antigens, Molecular Sequence Data, Molecular Weight, Oxidoreductases, N-Demethylating, Proteins/chemistry, T-Lymphocytes, Cytotoxic/immunology, X Chromosome, Y Chromosome",

author = "W Wang and Meadows, {L R} and {den Haan}, {J M} and Sherman, {N E} and Y Chen and E Blokland and J Shabanowitz and Agulnik, {A I} and Hendrickson, {R C} and Bishop, {C E}",

year = "1995",

month = sep,

day = "15",

language = "English",

volume = "269",

pages = "1588--90",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5230",

}

TY - JOUR

T1 - Human H-Y

T2 - a male-specific histocompatibility antigen derived from the SMCY protein

AU - Wang, W

AU - Meadows, L R

AU - den Haan, J M

AU - Sherman, N E

AU - Chen, Y

AU - Blokland, E

AU - Shabanowitz, J

AU - Agulnik, A I

AU - Hendrickson, R C

AU - Bishop, C E

PY - 1995/9/15

Y1 - 1995/9/15

N2 - H-Y is a transplantation antigen that can lead to rejection of male organ and bone marrow grafts by female recipients, even if the donor and recipient match at the major histocompatibility locus of humans, the HLA (human leukocyte antigen) locus. However, the origin and function of H-Y antigens has eluded researchers for 40 years. One human H-Y antigen presented by HLA-B7 was identified as an 11-residue peptide derived from SMCY, an evolutionarily conserved protein encoded on the Y chromosome. The protein from the homologous gene on the X chromosome, SMCX, differs by two amino acid residues in the same region. The identification of H-Y may aid in transplantation prognosis, prenatal diagnosis, and fertilization strategies.

AB - H-Y is a transplantation antigen that can lead to rejection of male organ and bone marrow grafts by female recipients, even if the donor and recipient match at the major histocompatibility locus of humans, the HLA (human leukocyte antigen) locus. However, the origin and function of H-Y antigens has eluded researchers for 40 years. One human H-Y antigen presented by HLA-B7 was identified as an 11-residue peptide derived from SMCY, an evolutionarily conserved protein encoded on the Y chromosome. The protein from the homologous gene on the X chromosome, SMCX, differs by two amino acid residues in the same region. The identification of H-Y may aid in transplantation prognosis, prenatal diagnosis, and fertilization strategies.

KW - Amino Acid Sequence

KW - B-Lymphocytes

KW - Cell Line

KW - Chromatography, High Pressure Liquid

KW - H-Y Antigen/chemistry

KW - HLA-B7 Antigen/immunology

KW - Histone Demethylases

KW - Histone-Lysine N-Methyltransferase

KW - Humans

KW - Male

KW - Mass Spectrometry/methods

KW - Minor Histocompatibility Antigens

KW - Molecular Sequence Data

KW - Molecular Weight

KW - Oxidoreductases, N-Demethylating

KW - Proteins/chemistry

KW - T-Lymphocytes, Cytotoxic/immunology

KW - X Chromosome

KW - Y Chromosome

M3 - Article

C2 - 7667640

SN - 0036-8075

VL - 269

SP - 1588

EP - 1590

JO - Science

JF - Science

IS - 5230

ER -