Human IgM antibodies do not activate guinea-pig complement after interaction with soluble antigen

J. S. van der Zee; E. C. Beuvery; R. van Ree; R. C. Aalberse

doi:https://doi.org/10.1016/0161-5890(86)90105-7

Human IgM antibodies do not activate guinea-pig complement after interaction with soluble antigen

J. S. van der Zee, E. C. Beuvery, R. van Ree, R. C. Aalberse

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8 Citations (Scopus)

Abstract

Activation of guinea-pig complement by human IgM antibodies after interaction with a particulate antigen is well established. Human IgM antibodies directed against meningococcal group-C capsular polysaccharide, however, were not able to fix guinea-pig complement in a classical complement fixation test with soluble antigen. In the same test, human complement was readily activated by these antibodies. This inability of human IgM antibodies to activate guinea-pig complement after interaction with soluble antigen was confirmed in other antigen systems. In contrast, efficient activation of both human and guinea-pig complement was found with the same antigen in a particulate form

Original language	English
Pages (from-to)	669-673
Journal	Molecular immunology
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/0161-5890(86)90105-7
Publication status	Published - 1986

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https://doi.org/10.1016/0161-5890(86)90105-7

Cite this

@article{43f4834332d34c05b012223ad18aa9e6,

title = "Human IgM antibodies do not activate guinea-pig complement after interaction with soluble antigen",

abstract = "Activation of guinea-pig complement by human IgM antibodies after interaction with a particulate antigen is well established. Human IgM antibodies directed against meningococcal group-C capsular polysaccharide, however, were not able to fix guinea-pig complement in a classical complement fixation test with soluble antigen. In the same test, human complement was readily activated by these antibodies. This inability of human IgM antibodies to activate guinea-pig complement after interaction with soluble antigen was confirmed in other antigen systems. In contrast, efficient activation of both human and guinea-pig complement was found with the same antigen in a particulate form",

author = "{van der Zee}, {J. S.} and Beuvery, {E. C.} and {van Ree}, R. and Aalberse, {R. C.}",

year = "1986",

doi = "https://doi.org/10.1016/0161-5890(86)90105-7",

language = "English",

volume = "23",

pages = "669--673",

journal = "Molecular immunology",

issn = "0161-5890",

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number = "6",

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T1 - Human IgM antibodies do not activate guinea-pig complement after interaction with soluble antigen

AU - van der Zee, J. S.

AU - Beuvery, E. C.

AU - van Ree, R.

AU - Aalberse, R. C.

PY - 1986

Y1 - 1986

N2 - Activation of guinea-pig complement by human IgM antibodies after interaction with a particulate antigen is well established. Human IgM antibodies directed against meningococcal group-C capsular polysaccharide, however, were not able to fix guinea-pig complement in a classical complement fixation test with soluble antigen. In the same test, human complement was readily activated by these antibodies. This inability of human IgM antibodies to activate guinea-pig complement after interaction with soluble antigen was confirmed in other antigen systems. In contrast, efficient activation of both human and guinea-pig complement was found with the same antigen in a particulate form

AB - Activation of guinea-pig complement by human IgM antibodies after interaction with a particulate antigen is well established. Human IgM antibodies directed against meningococcal group-C capsular polysaccharide, however, were not able to fix guinea-pig complement in a classical complement fixation test with soluble antigen. In the same test, human complement was readily activated by these antibodies. This inability of human IgM antibodies to activate guinea-pig complement after interaction with soluble antigen was confirmed in other antigen systems. In contrast, efficient activation of both human and guinea-pig complement was found with the same antigen in a particulate form

U2 - https://doi.org/10.1016/0161-5890(86)90105-7

DO - https://doi.org/10.1016/0161-5890(86)90105-7

M3 - Article

C2 - 3092033

SN - 0161-5890

VL - 23

SP - 669

EP - 673

JO - Molecular immunology

JF - Molecular immunology

IS - 6

ER -