Hydrogen sulfide producing enzymes in pregnancy and preeclampsia

K. M. Holwerda; E. M. Bos; A. Rajakumar; C. Ris-Stalpers; M. G. van Pampus; A. Timmer; J. J. H. M. Erwich; M. M. Faas; H. van Goor; A. T. Lely

doi:https://doi.org/10.1016/j.placenta.2012.02.014

Hydrogen sulfide producing enzymes in pregnancy and preeclampsia

K. M. Holwerda, E. M. Bos, A. Rajakumar, C. Ris-Stalpers, M. G. van Pampus, A. Timmer, J. J. H. M. Erwich, M. M. Faas, H. van Goor, A. T. Lely

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Abstract

Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H2S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H2S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H2S-producing enzymes cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H2S-production and may aid in the anti-angiogenic state. (C) 2012 Elsevier Ltd. All rights reserved

Original language	English
Pages (from-to)	518-521
Journal	Placenta
Volume	33
Issue number	6
DOIs	https://doi.org/10.1016/j.placenta.2012.02.014
Publication status	Published - 2012

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https://doi.org/10.1016/j.placenta.2012.02.014

Cite this

@article{7874ea51e67842a883b0548f903f1376,

title = "Hydrogen sulfide producing enzymes in pregnancy and preeclampsia",

abstract = "Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H2S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H2S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H2S-producing enzymes cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H2S-production and may aid in the anti-angiogenic state. (C) 2012 Elsevier Ltd. All rights reserved",

author = "Holwerda, {K. M.} and Bos, {E. M.} and A. Rajakumar and C. Ris-Stalpers and {van Pampus}, {M. G.} and A. Timmer and Erwich, {J. J. H. M.} and Faas, {M. M.} and {van Goor}, H. and Lely, {A. T.}",

year = "2012",

doi = "https://doi.org/10.1016/j.placenta.2012.02.014",

language = "English",

volume = "33",

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journal = "Placenta",

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TY - JOUR

T1 - Hydrogen sulfide producing enzymes in pregnancy and preeclampsia

AU - Holwerda, K. M.

AU - Bos, E. M.

AU - Rajakumar, A.

AU - Ris-Stalpers, C.

AU - van Pampus, M. G.

AU - Timmer, A.

AU - Erwich, J. J. H. M.

AU - Faas, M. M.

AU - van Goor, H.

AU - Lely, A. T.

PY - 2012

Y1 - 2012

N2 - Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H2S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H2S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H2S-producing enzymes cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H2S-production and may aid in the anti-angiogenic state. (C) 2012 Elsevier Ltd. All rights reserved

AB - Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H2S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H2S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H2S-producing enzymes cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H2S-production and may aid in the anti-angiogenic state. (C) 2012 Elsevier Ltd. All rights reserved

U2 - https://doi.org/10.1016/j.placenta.2012.02.014

DO - https://doi.org/10.1016/j.placenta.2012.02.014

M3 - Article

C2 - 22391326

SN - 0143-4004

VL - 33

SP - 518

EP - 521

JO - Placenta

JF - Placenta

IS - 6

ER -