TY - JOUR
T1 - Hypoglycaemia induces emotional disruption
AU - Merbis, M. A.
AU - Snoek, F. J.
AU - Kanc, K.
AU - Heine, R. J.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - This study investigated how hypoglycaemia affects mood, whether psychological characteristics mediate an emotional disturbance during hypoglycaemia. Ten IDDM patients (1 female) were studied, aged [mean (range)] 28 (20-37) years, body mass index (BMI) 23.4 (19.6-25.7) kg/m2, diabetes duration 11 (7-15) years, HbA1c 7.5 (6.0-8.7)%. Patients underwent a standardized stepwise, hypoglycaemic, hyperinsulinaemic clamp, performed in steps of 0.5 mmol/l from 4.0 mmol/l to a glucose nadir of 2.0 mmol/l. At euglycaemia, the Symptom Checklist-90 (SCL-90) was administered. The Profile of Mood States (POMS) was completed at 4.0 and 2.5 mmol/l, while the feelings chart of the COOP/WONCA was filled out at euglycaemia and all hypoglycaemic steps. The t-test for the POMS demonstrated a significant increase for anger (P <0.05). COOP/WONCA scores displayed a progressive negative change in mood for each hypoglycaemic step, albeit with a large interindividual variability. Hostility (SCL-90) significantly interacted with anger (POMS) at 2.5 mmol/l (P <0.05). Progression of hypoglycaemia negatively alters the overall mood state. IDDM patients characterised by high scores on hostility (SCL-90) apparently are more prone to experience an increase in anger (POMS) during hypoglycaemia
AB - This study investigated how hypoglycaemia affects mood, whether psychological characteristics mediate an emotional disturbance during hypoglycaemia. Ten IDDM patients (1 female) were studied, aged [mean (range)] 28 (20-37) years, body mass index (BMI) 23.4 (19.6-25.7) kg/m2, diabetes duration 11 (7-15) years, HbA1c 7.5 (6.0-8.7)%. Patients underwent a standardized stepwise, hypoglycaemic, hyperinsulinaemic clamp, performed in steps of 0.5 mmol/l from 4.0 mmol/l to a glucose nadir of 2.0 mmol/l. At euglycaemia, the Symptom Checklist-90 (SCL-90) was administered. The Profile of Mood States (POMS) was completed at 4.0 and 2.5 mmol/l, while the feelings chart of the COOP/WONCA was filled out at euglycaemia and all hypoglycaemic steps. The t-test for the POMS demonstrated a significant increase for anger (P <0.05). COOP/WONCA scores displayed a progressive negative change in mood for each hypoglycaemic step, albeit with a large interindividual variability. Hostility (SCL-90) significantly interacted with anger (POMS) at 2.5 mmol/l (P <0.05). Progression of hypoglycaemia negatively alters the overall mood state. IDDM patients characterised by high scores on hostility (SCL-90) apparently are more prone to experience an increase in anger (POMS) during hypoglycaemia
KW - Hostility
KW - Hypoglycaemia
KW - Mood
UR - http://www.scopus.com/inward/record.url?scp=0030272222&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/0738-3991(96)00940-8
DO - https://doi.org/10.1016/0738-3991(96)00940-8
M3 - Article
C2 - 9006228
SN - 0738-3991
VL - 29
SP - 117
EP - 122
JO - Patient Education and Counseling
JF - Patient Education and Counseling
IS - 1
ER -