Identification of a graft versus host disease-associated human minor histocompatibility antigen

J M den Haan; N E Sherman; E Blokland; E Huczko; F Koning; J W Drijfhout; J Skipper; J Shabanowitz; D F Hunt; V H Engelhard

Identification of a graft versus host disease-associated human minor histocompatibility antigen

J M den Haan, N E Sherman, E Blokland, E Huczko, F Koning, J W Drijfhout, J Skipper, J Shabanowitz, D F Hunt, V H Engelhard

Research output: Contribution to journal › Article › Academic › peer-review

374 Citations (Scopus)

Abstract

Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide appears to originate from a member of the non-filament-forming class I myosin family. Because HA-2 has a phenotype frequency of 95 percent in the HLA-A2.1-positive population, it is a candidate for immunotherapeutic intervention in bone marrow transplantation.

Original language	English
Pages (from-to)	1476-80
Number of pages	5
Journal	Science
Volume	268
Issue number	5216
Publication status	Published - 9 Jun 1995
Externally published	Yes

Keywords

Amino Acid Sequence
Bone Marrow Transplantation
Epitopes
Female
Graft vs Host Disease/immunology
HLA-A2 Antigen/immunology
Humans
Mass Spectrometry
Minor Histocompatibility Antigens/chemistry
Molecular Sequence Data
Neoplasm Proteins/chemistry
Oligopeptides/chemistry
T-Lymphocytes, Cytotoxic/immunology

Cite this

@article{810bbaa8eedc46bfbd01a4e64a47148d,

title = "Identification of a graft versus host disease-associated human minor histocompatibility antigen",

abstract = "Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide appears to originate from a member of the non-filament-forming class I myosin family. Because HA-2 has a phenotype frequency of 95 percent in the HLA-A2.1-positive population, it is a candidate for immunotherapeutic intervention in bone marrow transplantation.",

keywords = "Amino Acid Sequence, Bone Marrow Transplantation, Epitopes, Female, Graft vs Host Disease/immunology, HLA-A2 Antigen/immunology, Humans, Mass Spectrometry, Minor Histocompatibility Antigens/chemistry, Molecular Sequence Data, Neoplasm Proteins/chemistry, Oligopeptides/chemistry, T-Lymphocytes, Cytotoxic/immunology",

author = "{den Haan}, {J M} and Sherman, {N E} and E Blokland and E Huczko and F Koning and Drijfhout, {J W} and J Skipper and J Shabanowitz and Hunt, {D F} and Engelhard, {V H}",

year = "1995",

month = jun,

day = "9",

language = "English",

volume = "268",

pages = "1476--80",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5216",

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TY - JOUR

T1 - Identification of a graft versus host disease-associated human minor histocompatibility antigen

AU - den Haan, J M

AU - Sherman, N E

AU - Blokland, E

AU - Huczko, E

AU - Koning, F

AU - Drijfhout, J W

AU - Skipper, J

AU - Shabanowitz, J

AU - Hunt, D F

AU - Engelhard, V H

PY - 1995/6/9

Y1 - 1995/6/9

N2 - Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide appears to originate from a member of the non-filament-forming class I myosin family. Because HA-2 has a phenotype frequency of 95 percent in the HLA-A2.1-positive population, it is a candidate for immunotherapeutic intervention in bone marrow transplantation.

AB - Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide appears to originate from a member of the non-filament-forming class I myosin family. Because HA-2 has a phenotype frequency of 95 percent in the HLA-A2.1-positive population, it is a candidate for immunotherapeutic intervention in bone marrow transplantation.

KW - Amino Acid Sequence

KW - Bone Marrow Transplantation

KW - Epitopes

KW - Female

KW - Graft vs Host Disease/immunology

KW - HLA-A2 Antigen/immunology

KW - Humans

KW - Mass Spectrometry

KW - Minor Histocompatibility Antigens/chemistry

KW - Molecular Sequence Data

KW - Neoplasm Proteins/chemistry

KW - Oligopeptides/chemistry

KW - T-Lymphocytes, Cytotoxic/immunology

M3 - Article

C2 - 7539551

SN - 0036-8075

VL - 268

SP - 1476

EP - 1480

JO - Science

JF - Science

IS - 5216

ER -