Identification of a reduced folate/methotrexate carrier in human KB-cells expressing high levels of membrane associated folate binding protein

G R Westerhof, J H Schornagel, S Rijnboutt, H M Pinedo, G Jansen

Research output: Contribution to journalArticleAcademic

6 Citations (Scopus)
Original languageEnglish
Pages (from-to)771-4
Number of pages4
JournalAdvances in experimental medicine and biology
Publication statusPublished - 1993


  • Aminopterin/analogs & derivatives
  • Biological Transport/drug effects
  • Carrier Proteins/biosynthesis
  • Cell Division/drug effects
  • Cell Membrane/metabolism
  • Folate Receptors, GPI-Anchored
  • Folic Acid Antagonists/metabolism
  • Folic Acid/analogs & derivatives
  • Humans
  • KB Cells
  • Kinetics
  • Leucovorin/metabolism
  • Methotrexate/metabolism
  • Quinazolines/metabolism
  • Receptors, Cell Surface/metabolism
  • Structure-Activity Relationship

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