TY - JOUR
T1 - Idiopathic granulomatous mastitis
T2 - Long-discussed but yet-to-be-known
AU - Sheybani, Fereshte
AU - Naderi, Hamid Reza
AU - Gharib, Masoumeh
AU - Sarvghad, Mohammad Reza
AU - Mirfeizi, Zahra
N1 - Publisher Copyright: © 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2016/5/18
Y1 - 2016/5/18
N2 - Idiopathic granulomatous mastitis (IGM) is a chronic benign inflammatory disease of the breast with unknown etiology. It is an important diagnostic and therapeutic challenge, as most patients were initially misdiagnosed by their primary care physicians, leading to diagnostic confusion and heightened anxiety. Although several triggers have been proposed for development of IGM, the etiologic association of neither of them has been documented. Three main hypotheses about the possible causes of IGM have been suggested, including autoimmune response, infectious disease, and hormonal disruption. Here, we discuss a hypothetical perspective of IGM to explain the possible role of autoinflammation in the pathogenesis of the disease. We also reviewed the previously published literature on pathogenesis of IGM.
AB - Idiopathic granulomatous mastitis (IGM) is a chronic benign inflammatory disease of the breast with unknown etiology. It is an important diagnostic and therapeutic challenge, as most patients were initially misdiagnosed by their primary care physicians, leading to diagnostic confusion and heightened anxiety. Although several triggers have been proposed for development of IGM, the etiologic association of neither of them has been documented. Three main hypotheses about the possible causes of IGM have been suggested, including autoimmune response, infectious disease, and hormonal disruption. Here, we discuss a hypothetical perspective of IGM to explain the possible role of autoinflammation in the pathogenesis of the disease. We also reviewed the previously published literature on pathogenesis of IGM.
KW - Autoimmunity
KW - autoinflammation
KW - developing countries
KW - granulomatous mastitis
KW - infectious hypothesis
UR - http://www.scopus.com/inward/record.url?scp=84958062291&partnerID=8YFLogxK
U2 - https://doi.org/10.3109/08916934.2016.1138221
DO - https://doi.org/10.3109/08916934.2016.1138221
M3 - Article
C2 - 26829298
SN - 0891-6934
VL - 49
SP - 236
EP - 239
JO - Autoimmunity
JF - Autoimmunity
IS - 4
ER -