TY - JOUR
T1 - IgE antibodies to tetanus toxoid in relation to atopy
AU - Aalberse, R. C.
AU - van Ree, R.
AU - Danneman, A.
AU - Wahn, U.
PY - 1995
Y1 - 1995
N2 - In approximately 25% of subjects receiving tetanus booster immunization (4 study groups A-D with n = 6, 25, 50 and 240, respectively; age 18-40 years for groups A-C, age 2 for group D), substantial IgE antibody levels were found. In groups A and B, sequential serum samples were available for analysis. The IgE response peaked before the IgG response and was often higher at week 1 than at week 2. The 6 subjects in group A (military recruits) received 2 booster injections. At the time of the second injection, 2 subjects had a very high IgE antibody titre (as well as a high IgG antibody titre), but no signs of an allergic reaction were noted. A significant association with atopy-related factors was found, but many apparently non-atopic subjects developed IgE antibodies
AB - In approximately 25% of subjects receiving tetanus booster immunization (4 study groups A-D with n = 6, 25, 50 and 240, respectively; age 18-40 years for groups A-C, age 2 for group D), substantial IgE antibody levels were found. In groups A and B, sequential serum samples were available for analysis. The IgE response peaked before the IgG response and was often higher at week 1 than at week 2. The 6 subjects in group A (military recruits) received 2 booster injections. At the time of the second injection, 2 subjects had a very high IgE antibody titre (as well as a high IgG antibody titre), but no signs of an allergic reaction were noted. A significant association with atopy-related factors was found, but many apparently non-atopic subjects developed IgE antibodies
U2 - https://doi.org/10.1159/000236967
DO - https://doi.org/10.1159/000236967
M3 - Article
C2 - 7613125
SN - 1018-2438
VL - 107
SP - 169
EP - 171
JO - International archives of allergy and immunology
JF - International archives of allergy and immunology
IS - 1-3
ER -