TY - JOUR
T1 - IL-4 expression by neutrophils in psoriasis lesional skin upon high-dose UVB exposure
AU - Piskin, Gamze
AU - Tursen, Umit
AU - Bos, Jan D.
AU - Teunissen, Marcel B. M.
PY - 2003
Y1 - 2003
N2 - Background, Upon a single high dose of UVB irradiation of psoriatic lesional skin, IFN-gamma expression is decreased, whereas IL-4 expression is enhanced. A similar type 1 to type 2 shift was found in dermal T cells derived from irradiated lesional skin as compared to unexposed lesional psoriatic skin. We have found recently that the IL-4 protein detected in situ upon UVB exposure of normal skin was not associated with T cells but with infiltrating neutrophils. Objective: To determine which cell types express IL-4 in psoriatic skin after UV8 irradiation. Methods: Skin biopsies were obtained from healthy controls and psoriasis patients before and after local UVB exposure. Double immunohistochemical stainings were performed to determine the identity of IL-4-expressing cells. Results: In the irradiated skin of both healthy controls and patients, IL-4-positive cells coexpressed elastase and CD15, but not CD3. Conclusion: IL-4-expressing cells found in psoriatic skin after a single high-dose UVB exposure appeared to be neutrophils. Copyright (C) 2003 S. Karger AG, Basel
AB - Background, Upon a single high dose of UVB irradiation of psoriatic lesional skin, IFN-gamma expression is decreased, whereas IL-4 expression is enhanced. A similar type 1 to type 2 shift was found in dermal T cells derived from irradiated lesional skin as compared to unexposed lesional psoriatic skin. We have found recently that the IL-4 protein detected in situ upon UVB exposure of normal skin was not associated with T cells but with infiltrating neutrophils. Objective: To determine which cell types express IL-4 in psoriatic skin after UV8 irradiation. Methods: Skin biopsies were obtained from healthy controls and psoriasis patients before and after local UVB exposure. Double immunohistochemical stainings were performed to determine the identity of IL-4-expressing cells. Results: In the irradiated skin of both healthy controls and patients, IL-4-positive cells coexpressed elastase and CD15, but not CD3. Conclusion: IL-4-expressing cells found in psoriatic skin after a single high-dose UVB exposure appeared to be neutrophils. Copyright (C) 2003 S. Karger AG, Basel
U2 - https://doi.org/10.1159/000070942
DO - https://doi.org/10.1159/000070942
M3 - Article
C2 - 12835549
SN - 1018-8665
VL - 207
SP - 51
EP - 53
JO - Dermatology (Basel, Switzerland)
JF - Dermatology (Basel, Switzerland)
IS - 1
ER -