Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig

W. J. van der Giessen; B. Schoutsen; J. G. Tijssen; P. D. Verdouw

Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig

W. J. van der Giessen, B. Schoutsen, J. G. Tijssen, P. D. Verdouw

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Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Ligation of the left anterior descending coronary artery in open-chest pigs for 20 min caused a complete loss of regional myocardial function, which did not recover during the first two hours of reperfusion. Infusion of the stable prostacyclin analogue Iloprost (100 ng kg-1 min-1) did not prevent the loss of systolic wall function during ischaemia. Recovery of regional myocardial function during the first two hours of reperfusion was enhanced to 40% of baseline by Iloprost. This effect of Iloprost cannot be explained by a decreased O2-demand during ischaemia or an enhanced recovery of myocardial ATP content

Original language	English
Pages (from-to)	23-27
Journal	British journal of pharmacology
Volume	87
Issue number	1
Publication status	Published - 1986

Cite this

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title = "Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig",

abstract = "Ligation of the left anterior descending coronary artery in open-chest pigs for 20 min caused a complete loss of regional myocardial function, which did not recover during the first two hours of reperfusion. Infusion of the stable prostacyclin analogue Iloprost (100 ng kg-1 min-1) did not prevent the loss of systolic wall function during ischaemia. Recovery of regional myocardial function during the first two hours of reperfusion was enhanced to 40% of baseline by Iloprost. This effect of Iloprost cannot be explained by a decreased O2-demand during ischaemia or an enhanced recovery of myocardial ATP content",

author = "{van der Giessen}, {W. J.} and B. Schoutsen and Tijssen, {J. G.} and Verdouw, {P. D.}",

year = "1986",

language = "English",

volume = "87",

pages = "23--27",

journal = "British journal of pharmacology",

issn = "0007-1188",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig

AU - van der Giessen, W. J.

AU - Schoutsen, B.

AU - Tijssen, J. G.

AU - Verdouw, P. D.

PY - 1986

Y1 - 1986

N2 - Ligation of the left anterior descending coronary artery in open-chest pigs for 20 min caused a complete loss of regional myocardial function, which did not recover during the first two hours of reperfusion. Infusion of the stable prostacyclin analogue Iloprost (100 ng kg-1 min-1) did not prevent the loss of systolic wall function during ischaemia. Recovery of regional myocardial function during the first two hours of reperfusion was enhanced to 40% of baseline by Iloprost. This effect of Iloprost cannot be explained by a decreased O2-demand during ischaemia or an enhanced recovery of myocardial ATP content

AB - Ligation of the left anterior descending coronary artery in open-chest pigs for 20 min caused a complete loss of regional myocardial function, which did not recover during the first two hours of reperfusion. Infusion of the stable prostacyclin analogue Iloprost (100 ng kg-1 min-1) did not prevent the loss of systolic wall function during ischaemia. Recovery of regional myocardial function during the first two hours of reperfusion was enhanced to 40% of baseline by Iloprost. This effect of Iloprost cannot be explained by a decreased O2-demand during ischaemia or an enhanced recovery of myocardial ATP content

M3 - Article

C2 - 2420399

SN - 0007-1188

VL - 87

SP - 23

EP - 27

JO - British journal of pharmacology

JF - British journal of pharmacology

IS - 1

ER -