TY - JOUR
T1 - Imaging Biomarkers for Intra-arterial Stroke Therapy
AU - Berkhemer, Olvert A.
AU - Kamalian, Shervin
AU - González, R. Gilberto
AU - Majoie, Charles B. L. M.
AU - Yoo, Albert J.
PY - 2013
Y1 - 2013
N2 - Despite high rates of early revascularization with intra-arterial stroke therapy, the clinical efficacy of this approach has not been clearly demonstrated. Neuroimaging biomarkers will be useful in future trials for patient selection and for outcomes evaluation. To identify patients who are likely to benefit from intra-arterial therapy, the combination of vessel imaging, infarct size quantification and degree of neurologic deficit appears critical. Perfusion imaging may be useful in specific circumstances, but requires further validation. For measuring treatment outcomes, surrogate biomarkers that appear suitable are angiographic reperfusion as measured by the modified Thrombolysis in Cerebral Infarction scale and final infarct volume
AB - Despite high rates of early revascularization with intra-arterial stroke therapy, the clinical efficacy of this approach has not been clearly demonstrated. Neuroimaging biomarkers will be useful in future trials for patient selection and for outcomes evaluation. To identify patients who are likely to benefit from intra-arterial therapy, the combination of vessel imaging, infarct size quantification and degree of neurologic deficit appears critical. Perfusion imaging may be useful in specific circumstances, but requires further validation. For measuring treatment outcomes, surrogate biomarkers that appear suitable are angiographic reperfusion as measured by the modified Thrombolysis in Cerebral Infarction scale and final infarct volume
U2 - https://doi.org/10.1007/s13239-013-0148-4
DO - https://doi.org/10.1007/s13239-013-0148-4
M3 - Article
C2 - 24932316
SN - 1869-408X
VL - 4
SP - 339
EP - 351
JO - Cardiovascular Engineering and Technology
JF - Cardiovascular Engineering and Technology
IS - 4
ER -