Imaging tests for the diagnosis of COVID-19

Matthew D. F. McInnes, Mariska M. G. Leeflang, Jean-Paul Salameh, Trevor A. McGrath, Christian B. van der Pol, Robert A. Frank, Ross Prager, Samanjit S. Hare, Carole Dennie, René Spijker, Jonathan J. Deeks, Jacqueline Dinnes, Kevin Jenniskens, Daniël A. Korevaar, J. rémie F. Cohen, Ann van den Bruel, Yemisi Takwoingi, Janneke van de Wijgert, Johanna A. AG Damen, Lotty Hooft

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Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. The primary objective is to determine the diagnostic accuracy of chest imaging (computed tomography (CT), chest X-ray and ultrasound) in the evaluation of people suspected to have COVID-19. This may also refer to specific signs, such as a particular CT finding. Secondary objectives To evaluate whether these imaging tests are sufficiently accurate to rule out COVID-19 (main measure of interest will be the negative predictive value) To evaluate the rate of positive imaging in patients with initial RT-PCR negative results who have a positive result on a follow-up RT-PCR test To determine if there is an association between number of days after symptom onset, symptom severity and the findings on chest imaging for patients with COVID-19 To determine the rate of discrepancy or agreement between CT, chest X-ray and ultrasound findings To evaluate for ‘threshold’ effects of imaging findings of COVID-19 and accuracy measures To determine the rate of alternative diagnoses identified by chest imaging.
Original languageEnglish
Article numberCD013639
JournalCochrane database of systematic reviews (Online)
Issue number6
Publication statusPublished - 2 Jun 2020

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