Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis

Annemarie E. Brouwer; Asna A. Siddiqui; Maartje I. Kester; Kim C.E. Sigaloff; Adul Rajanuwong; Saran Wannapasni; Wirongrong Chierakul; Thomas S. Harrison

doi:https://doi.org/10.1016/j.jinf.2006.10.002

Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis

Annemarie E. Brouwer, Asna A. Siddiqui, Maartje I. Kester, Kim C.E. Sigaloff, Adul Rajanuwong, Saran Wannapasni, Wirongrong Chierakul, Thomas S. Harrison

Research output: Contribution to journal › Article › Academic › peer-review

32 Citations (Scopus)

Abstract

The pathophysiology of meningitis caused by Cryptococcus gattii in apparently immunocompetent individuals remains unclear. We measured multiple cytokines in CSF from a HIV-seronegative, apparently immunocompetent, Thai patient with C. gattii meningitis, over the first 2 weeks of antifungal therapy. Levels of proinflammatory IFN-γ, TNF-α, and IL-6 were very low compared to patients with HIV-related Cryptococcus neoformans meningitis and of IL-10 very high. While patients with C. gattii meningitis may be a heterogeneous group, these data suggest in this case a maladapted immune response to cryptococcal exposure had allowed progression to clinical cryptococcal disease.

Original language	English
Pages (from-to)	e165-e168
Journal	Journal of Infection
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/j.jinf.2006.10.002
Publication status	Published - 1 Mar 2007

Keywords

Cerebrospinal fluid
Cryptococcal
Cryptococcus
Cytokines
Immunology
Immunotherapy
Meningitis

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https://doi.org/10.1016/j.jinf.2006.10.002

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title = "Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis",

abstract = "The pathophysiology of meningitis caused by Cryptococcus gattii in apparently immunocompetent individuals remains unclear. We measured multiple cytokines in CSF from a HIV-seronegative, apparently immunocompetent, Thai patient with C. gattii meningitis, over the first 2 weeks of antifungal therapy. Levels of proinflammatory IFN-γ, TNF-α, and IL-6 were very low compared to patients with HIV-related Cryptococcus neoformans meningitis and of IL-10 very high. While patients with C. gattii meningitis may be a heterogeneous group, these data suggest in this case a maladapted immune response to cryptococcal exposure had allowed progression to clinical cryptococcal disease.",

keywords = "Cerebrospinal fluid, Cryptococcal, Cryptococcus, Cytokines, Immunology, Immunotherapy, Meningitis",

author = "Brouwer, {Annemarie E.} and Siddiqui, {Asna A.} and Kester, {Maartje I.} and Sigaloff, {Kim C.E.} and Adul Rajanuwong and Saran Wannapasni and Wirongrong Chierakul and Harrison, {Thomas S.}",

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AU - Brouwer, Annemarie E.

AU - Siddiqui, Asna A.

AU - Kester, Maartje I.

AU - Sigaloff, Kim C.E.

AU - Rajanuwong, Adul

AU - Wannapasni, Saran

AU - Chierakul, Wirongrong

AU - Harrison, Thomas S.

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AB - The pathophysiology of meningitis caused by Cryptococcus gattii in apparently immunocompetent individuals remains unclear. We measured multiple cytokines in CSF from a HIV-seronegative, apparently immunocompetent, Thai patient with C. gattii meningitis, over the first 2 weeks of antifungal therapy. Levels of proinflammatory IFN-γ, TNF-α, and IL-6 were very low compared to patients with HIV-related Cryptococcus neoformans meningitis and of IL-10 very high. While patients with C. gattii meningitis may be a heterogeneous group, these data suggest in this case a maladapted immune response to cryptococcal exposure had allowed progression to clinical cryptococcal disease.

KW - Cerebrospinal fluid

KW - Cryptococcal

KW - Cryptococcus

KW - Cytokines

KW - Immunology

KW - Immunotherapy

KW - Meningitis

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Immune dysfunction in HIV-seronegative, Cryptococcus gattii meningitis

Abstract

Keywords

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