TY - JOUR
T1 - Immunogenicity of biological therapeutics: from assay to patient
AU - Krieckaert, Charlotte
AU - Rispens, Theo
AU - Wolbink, Gertjan
PY - 2012
Y1 - 2012
N2 - Purpose of review To give an overview of the current knowledge on assay techniques and clinical implications of immunogenicity of biological therapeutics. Recent findings Assay techniques for the measurement of immunogenicity have improved, expanding the understanding of the immune response against biological therapeutics. Knowledge on the clinical effect of immunogenicity enables the treatment of patients in a targeted fashion, as a step towards personalized medicine. Summary Biological medications are able to induce an antidrug immune response. Immunogenicity impairs clinical response and is associated with adverse events. Several confounding factors influence the measurement of immunogenicity, including drug interference and background problems. Concomitant administration of methotrexate lowers the frequency and amount of antibodies formed, whereby the efficacy of biologicals is improved. Algorithms for therapeutic drug monitoring could aid in adapting treatment strategies in a controlled setting
AB - Purpose of review To give an overview of the current knowledge on assay techniques and clinical implications of immunogenicity of biological therapeutics. Recent findings Assay techniques for the measurement of immunogenicity have improved, expanding the understanding of the immune response against biological therapeutics. Knowledge on the clinical effect of immunogenicity enables the treatment of patients in a targeted fashion, as a step towards personalized medicine. Summary Biological medications are able to induce an antidrug immune response. Immunogenicity impairs clinical response and is associated with adverse events. Several confounding factors influence the measurement of immunogenicity, including drug interference and background problems. Concomitant administration of methotrexate lowers the frequency and amount of antibodies formed, whereby the efficacy of biologicals is improved. Algorithms for therapeutic drug monitoring could aid in adapting treatment strategies in a controlled setting
U2 - https://doi.org/10.1097/BOR.0b013e3283521c4e
DO - https://doi.org/10.1097/BOR.0b013e3283521c4e
M3 - Review article
C2 - 22388644
SN - 1040-8711
VL - 24
SP - 306
EP - 311
JO - Current Opinion in Rheumatology
JF - Current Opinion in Rheumatology
IS - 3
ER -