Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications

Jessica Roelands; Peter J. K. Kuppen; Louis Vermeulen; Cristina Maccalli; Julie Decock; Ena Wang; Francesco M. Marincola; Davide Bedognetti; Wouter Hendrickx

doi:https://doi.org/10.3390/ijms18102229

Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications

Jessica Roelands, Peter J. K. Kuppen, Louis Vermeulen, Cristina Maccalli, Julie Decock, Ena Wang, Francesco M. Marincola, Davide Bedognetti, Wouter Hendrickx

Research output: Contribution to journal › Review article › Academic › peer-review

99 Citations (Scopus)

Abstract

The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) has led to the identification of favorable and unfavorable immunological attributes linked to clinical outcome. With the definition of consensus molecular subtypes (CMSs) based on transcriptomic profiles, multiple characteristics have been proposed to be responsible for the development of the tumor immune microenvironment and corresponding mechanisms of immune escape. In this review, a detailed description of proposed immune phenotypes as well as their interaction with different therapeutic modalities will be provided. Finally, possible strategies to shift the CRC immune phenotype towards a reactive, anti-tumor orientation are proposed per CMS

Original language	English
Pages (from-to)	2229
Journal	International journal of molecular sciences
Volume	18
Issue number	10
Early online date	2017
DOIs	https://doi.org/10.3390/ijms18102229
Publication status	Published - 2017

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https://doi.org/10.3390/ijms18102229

Cite this

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title = "Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications",

abstract = "The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) has led to the identification of favorable and unfavorable immunological attributes linked to clinical outcome. With the definition of consensus molecular subtypes (CMSs) based on transcriptomic profiles, multiple characteristics have been proposed to be responsible for the development of the tumor immune microenvironment and corresponding mechanisms of immune escape. In this review, a detailed description of proposed immune phenotypes as well as their interaction with different therapeutic modalities will be provided. Finally, possible strategies to shift the CRC immune phenotype towards a reactive, anti-tumor orientation are proposed per CMS",

author = "Jessica Roelands and Kuppen, {Peter J. K.} and Louis Vermeulen and Cristina Maccalli and Julie Decock and Ena Wang and Marincola, {Francesco M.} and Davide Bedognetti and Wouter Hendrickx",

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AU - Roelands, Jessica

AU - Kuppen, Peter J. K.

AU - Vermeulen, Louis

AU - Maccalli, Cristina

AU - Decock, Julie

AU - Wang, Ena

AU - Marincola, Francesco M.

AU - Bedognetti, Davide

AU - Hendrickx, Wouter

PY - 2017

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N2 - The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) has led to the identification of favorable and unfavorable immunological attributes linked to clinical outcome. With the definition of consensus molecular subtypes (CMSs) based on transcriptomic profiles, multiple characteristics have been proposed to be responsible for the development of the tumor immune microenvironment and corresponding mechanisms of immune escape. In this review, a detailed description of proposed immune phenotypes as well as their interaction with different therapeutic modalities will be provided. Finally, possible strategies to shift the CRC immune phenotype towards a reactive, anti-tumor orientation are proposed per CMS

AB - The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) has led to the identification of favorable and unfavorable immunological attributes linked to clinical outcome. With the definition of consensus molecular subtypes (CMSs) based on transcriptomic profiles, multiple characteristics have been proposed to be responsible for the development of the tumor immune microenvironment and corresponding mechanisms of immune escape. In this review, a detailed description of proposed immune phenotypes as well as their interaction with different therapeutic modalities will be provided. Finally, possible strategies to shift the CRC immune phenotype towards a reactive, anti-tumor orientation are proposed per CMS

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DO - https://doi.org/10.3390/ijms18102229

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