TY - JOUR
T1 - Immunoglobulin G4-mediated sclerosing cholangitis as a risk factor for cholangiocarcinoma
T2 - A case report
AU - Koopman, Karin E
AU - Bloemena, Elisabeth
AU - Kazemier, Geert
AU - Klemt-Kropp, Michael
PY - 2016/12
Y1 - 2016/12
N2 - Immunoglobulin (Ig)G4-mediated disease is a systemic autoimmune disease, which occasionally presents solely as sclerosing cholangitis (SC). IgG4-mediated SC is challenging to diagnose, as it may mimic cholangiocarcinoma radiologically, and carcinoma cells may produce IgG4. The diagnosis of IgG4-mediated disease is based on histological consensus criteria and response to corticosteroids. In addition to the radiological and histological overlap between IgG4-mediated SC and cholangiocarcinoma, IgG4-mediated SC may be considered as a risk factor for the development of cholangiocarcinoma. We herein present the case of a patient in whom cholangiocarcinoma developed in two lesions previously characterized as IgG4-mediated SC, including a suggested mechanism underlying the contribution of IgG4-mediated SC to the development of cholangiocarcinoma.
AB - Immunoglobulin (Ig)G4-mediated disease is a systemic autoimmune disease, which occasionally presents solely as sclerosing cholangitis (SC). IgG4-mediated SC is challenging to diagnose, as it may mimic cholangiocarcinoma radiologically, and carcinoma cells may produce IgG4. The diagnosis of IgG4-mediated disease is based on histological consensus criteria and response to corticosteroids. In addition to the radiological and histological overlap between IgG4-mediated SC and cholangiocarcinoma, IgG4-mediated SC may be considered as a risk factor for the development of cholangiocarcinoma. We herein present the case of a patient in whom cholangiocarcinoma developed in two lesions previously characterized as IgG4-mediated SC, including a suggested mechanism underlying the contribution of IgG4-mediated SC to the development of cholangiocarcinoma.
U2 - https://doi.org/10.3892/mco.2016.1040
DO - https://doi.org/10.3892/mco.2016.1040
M3 - Article
C2 - 28105357
SN - 2049-9450
VL - 5
SP - 786
EP - 788
JO - Journal of clinical oncology
JF - Journal of clinical oncology
IS - 6
ER -