@article{81e86a977df549c1a7d6fa843713cc39,
title = "Immunoglobulin M-enriched intravenous polyclonal immunoglobulins reduce bacteremia following Klebsiella pneumoniae infection in an acute respiratory distress syndrome rat model",
abstract = "Mechanical ventilation is known to induce bacterial translocation from the lung into the systemic circulation. This study determined the effect of immunoglobulin M (IgM)-enriched polyclonal immunoglobulins on bacteremia due to ventilation-induced translocation in an acute respiratory distress syndrome (ARDS) rat model with Klebsiella-induced pneumonia. After whole lung lavage, Sprague-Dawley rats intravenously received either a high dose or a low dose of an immunoglobulin preparation, or an albumin solution as control, followed by an intratracheal injection of a Klebsiella pneumoniae solution. Blood colony-forming units (CFUs) in the treatment groups were significantly lower during the 3-hour ventilation period compared to the control group. The authors conclude that IgM-enriched polyclonal immunoglobulins lead to a reduction of bacteria in blood of surfactant-deficient, ventilated rats infected with Klebsiella pneumoniae.",
keywords = "Bronchoalveolar lavage, CFUs, Klebsiella pneumoniae, Pentaglobin, Rat",
author = "Lachmann, {R. A.} and {Van Kaam}, {A. H.L.C.} and Haitsma, {J. J.} and Verbrugge, {S. J.C.} and F. Delreu and B. Lachmann",
note = "Funding Information: Received 9 June 2003; accepted 23 July 2003. The work was performed at the Department of Anesthesiology, Erasmus MC-Faculty. This study was financially supported by the International Foundation for Clinically Oriented Research (IFCOR). Pentaglobin was a gift from Biotest, Dreieich, Germany. There was no conflict of interest using this immunoglobulin preparation. Address correspondence to Prof. Dr. B. Lachmann, Department of Anesthesiology (Room EE 2393), Erasmus MC-Faculty, Dr. Molewaterplein 50, 3015 GE Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands. E-mail: b.lachmann@erasmusmc.nl The author thank Stefan Krabbendam (Erasmus MC-Faculty) for expert technical assistance and Laraine Visser-Isles (Erasmus MC-Faculty) for English language editing.",
year = "2004",
month = jun,
doi = "https://doi.org/10.1080/01902140490439013",
language = "English",
volume = "30",
pages = "251--260",
journal = "Experimental lung research",
issn = "0190-2148",
publisher = "Informa Healthcare",
number = "4",
}