TY - JOUR
T1 - Immunoglobulins and complement factors in senile plaques. An immunoperoxidase study
AU - Eikelenboom, P.
AU - Stam, F. C.
PY - 1982
Y1 - 1982
N2 - Immunoperoxidase techniques were used to obtain information about the possible presence of serum factors in senile plaques. We found only in plaques consisting of an amyloid core surrounded by a corona of degenerating neurites small amounts of IgG and light chains (kappa and lambda). These immunoglobulins were principally localized in the corona and not in the central amyloid core. Further it was found that all plaques contain the complement factors C1q, C3b, C3c, C3d and C4. Senile plaques lacked C5, C3 pro-activator and properdin. The possible significance of these findings in the genesis of the senile plaques and amyloid formation is discussed
AB - Immunoperoxidase techniques were used to obtain information about the possible presence of serum factors in senile plaques. We found only in plaques consisting of an amyloid core surrounded by a corona of degenerating neurites small amounts of IgG and light chains (kappa and lambda). These immunoglobulins were principally localized in the corona and not in the central amyloid core. Further it was found that all plaques contain the complement factors C1q, C3b, C3c, C3d and C4. Senile plaques lacked C5, C3 pro-activator and properdin. The possible significance of these findings in the genesis of the senile plaques and amyloid formation is discussed
U2 - https://doi.org/10.1007/BF00685397
DO - https://doi.org/10.1007/BF00685397
M3 - Comment/Letter to the editor
C2 - 6812382
SN - 0001-6322
VL - 57
SP - 239
EP - 242
JO - Acta Neuropathologica
JF - Acta Neuropathologica
IS - 2-3
ER -