TY - JOUR
T1 - Immunological Analysis of Treatment Interruption After Early Highly Active Antiretroviral Therapy
AU - Schellens, Ingrid M. M.
AU - Pogany, Katalin
AU - Westerlaken, Geertje H. A.
AU - Borghans, José A. M.
AU - Miedema, Frank
AU - van Valkengoed, Irene G. M.
AU - Kroon, Frank P.
AU - Lange, Joep M. A.
AU - Brinkman, Kees
AU - Prins, Jan M.
AU - van Baarle, Debbie
PY - 2010
Y1 - 2010
N2 - We longitudinally evaluated HIV-specific T-cell immunity after discontinuation of highly active antiretroviral therapy (HAART). After treatment interruption (TI), some individuals could maintain a low plasma viral load ( <15,000 copies/mL), whereas others could not (>50,000 copies/mL). Before HAART was initiated, plasma viral load was similar. After TI, the numbers of CD8(+) T cells increased more in individuals without viral control, whereas individuals maintaining a low viral load showed a more pronounced increase in HIV-specific CD8(+) T-cell numbers. No differences were seen in the number or percentage of cytokine-producing HIV-1-specific CD4(+) T cells, or in proliferative capacity of T cells. Four weeks after TI, the magnitude of the total HIV-1-specific CD8(+) T-cell response (IFN-gamma(+) and/or IL-2(+) and/or CD107a(+)) was significantly higher in individuals maintaining viral control. Degranulation contributed more to the overall CD8(+) T-cell response than cytokine production. Whether increased T-cell functionality is a cause or consequence of low viral load remains to be elucidated
AB - We longitudinally evaluated HIV-specific T-cell immunity after discontinuation of highly active antiretroviral therapy (HAART). After treatment interruption (TI), some individuals could maintain a low plasma viral load ( <15,000 copies/mL), whereas others could not (>50,000 copies/mL). Before HAART was initiated, plasma viral load was similar. After TI, the numbers of CD8(+) T cells increased more in individuals without viral control, whereas individuals maintaining a low viral load showed a more pronounced increase in HIV-specific CD8(+) T-cell numbers. No differences were seen in the number or percentage of cytokine-producing HIV-1-specific CD4(+) T cells, or in proliferative capacity of T cells. Four weeks after TI, the magnitude of the total HIV-1-specific CD8(+) T-cell response (IFN-gamma(+) and/or IL-2(+) and/or CD107a(+)) was significantly higher in individuals maintaining viral control. Degranulation contributed more to the overall CD8(+) T-cell response than cytokine production. Whether increased T-cell functionality is a cause or consequence of low viral load remains to be elucidated
U2 - https://doi.org/10.1089/vim.2010.0062
DO - https://doi.org/10.1089/vim.2010.0062
M3 - Article
C2 - 21142446
SN - 0882-8245
VL - 23
SP - 609
EP - 618
JO - Viral immunology
JF - Viral immunology
IS - 6
ER -