Immunology and barrier function of the skin

Thomas Rustemeyer, Manigé Fartasch

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

1 Citation (Scopus)


A disturbed epidermal barrier may lead to irritant contact dermatitis. An enhanced penetration through skin barrier may facilitate sensitization. Immunological effects induced by pre-irritation and barrier alteration may further lead to the induction of allergic Type IV-contact dermatitis and Type I (immediate-type reaction) reactions or aggravate allergic reactions.

Original languageEnglish
Title of host publicationKanerva's Occupational Dermatology
PublisherSpringer International Publishing AG
Number of pages8
ISBN (Electronic)9783319686172
ISBN (Print)9783319686158
Publication statusPublished - 1 Jan 2019


  • Atopic eczema (AE)
  • Cornified cell envelope
  • Epidermal permeability barrier
  • Filaggrin
  • Keratohyalin
  • Netherton’s syndrome (NS)
  • Transepidermal water loss (TEWL)

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