Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [O-15]H2O PET study

I. Danad; P.G. Raijmakers; H.J. Harms; M.W. Heymans; N. van Royen; M. Lubberink; R. Boellaard; A.C. van Rossum; A.A. Lammertsma; P. Knaapen

doi:https://doi.org/10.1093/eurheartj/ehu170

Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [O-15]H2O PET study

I. Danad, P.G. Raijmakers, H.J. Harms, M.W. Heymans, N. van Royen, M. Lubberink, R. Boellaard, A.C. van Rossum, A.A. Lammertsma, P. Knaapen

Research output: Contribution to journal › Article › Academic › peer-review

60 Citations (Scopus)

Abstract

Background :Myocardial ischaemia occurs principally in the subendocardial layer, whereas conventional myocardial perfusion imaging provides no information on the transmural myocardial blood flow (MBF) distribution. Subendocardial perfusion measurements and quantification of the transmural perfusion gradient (TPG) could be more sensitive and specific for the detection of coronary artery disease (CAD). The current study aimed to determine the impact of lesion severity as assessed by the fractional flow reserve (FFR) on subendocardial perfusion and the TPG using

Original language	English
Pages (from-to)	2094-2105
Journal	European Heart journal
Volume	35
Issue number	31
DOIs	https://doi.org/10.1093/eurheartj/ehu170
Publication status	Published - 2014

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https://doi.org/10.1093/eurheartj/ehu170

Cite this

Danad, I., Raijmakers, P. G., Harms, H. J., Heymans, M. W., van Royen, N., Lubberink, M., Boellaard, R., van Rossum, A. C., Lammertsma, A. A., & Knaapen, P. (2014). Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [O-15]H2O PET study. European Heart journal, 35(31), 2094-2105. https://doi.org/10.1093/eurheartj/ehu170

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abstract = "Background :Myocardial ischaemia occurs principally in the subendocardial layer, whereas conventional myocardial perfusion imaging provides no information on the transmural myocardial blood flow (MBF) distribution. Subendocardial perfusion measurements and quantification of the transmural perfusion gradient (TPG) could be more sensitive and specific for the detection of coronary artery disease (CAD). The current study aimed to determine the impact of lesion severity as assessed by the fractional flow reserve (FFR) on subendocardial perfusion and the TPG using",

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Danad, I , Raijmakers, PG, Harms, HJ, Heymans, MW, van Royen, N, Lubberink, M, Boellaard, R , van Rossum, AC , Lammertsma, AA & Knaapen, P 2014, 'Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [O-15]H2O PET study', European Heart journal, vol. 35, no. 31, pp. 2094-2105. https://doi.org/10.1093/eurheartj/ehu170

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T1 - Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [O-15]H2O PET study

AU - Danad, I.

AU - Raijmakers, P.G.

AU - Harms, H.J.

AU - Heymans, M.W.

AU - van Royen, N.

AU - Lubberink, M.

AU - Boellaard, R.

AU - van Rossum, A.C.

AU - Lammertsma, A.A.

AU - Knaapen, P.

PY - 2014

Y1 - 2014

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AB - Background :Myocardial ischaemia occurs principally in the subendocardial layer, whereas conventional myocardial perfusion imaging provides no information on the transmural myocardial blood flow (MBF) distribution. Subendocardial perfusion measurements and quantification of the transmural perfusion gradient (TPG) could be more sensitive and specific for the detection of coronary artery disease (CAD). The current study aimed to determine the impact of lesion severity as assessed by the fractional flow reserve (FFR) on subendocardial perfusion and the TPG using

U2 - https://doi.org/10.1093/eurheartj/ehu170

DO - https://doi.org/10.1093/eurheartj/ehu170

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