Impact of chronic hepatitis C and/or D on liver fibrosis severity in patients co-infected with HIV and hepatitis B virus

Karine Lacombe, Anders Boyd, Moise Desvarieux, Lawrence Serfaty, Philippe Bonnord, Joel Gozlan, Jean-Michel Molina, Patrick Miailhes, Caroline Lascoux-Combe, Elyanne Gault, Pierre-Marie Girard

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25 Citations (Scopus)

Abstract

The histological study on the reciprocal influence of chronic hepatitis C (HCV) and/or delta (HDV) on liver damage in a cohort of 134 HIV-HBV co-infected patients concluded on a significant association between HDV co-infection (noted in 13 patients) and Metavir F3-F4 liver fibrosis score [odds ratio (OR) = 7.08, 95% confidence interval (CI) = 1.06-47.28 for HBV-HDV, OR = 10.02, 95% CI = 1.03-97.42 for HBV-HCV-HDV, compared to OR = 1.76, 95% CI = 0.50-6.17 for HBV alone]. Co-treatment of other multiple viral hepatitis infections should also be taken into consideration, especially in the case of chronic HDV. © 2007 Lippincott Williams & Wilkins, Inc.
Original languageEnglish
Pages (from-to)2546-2549
Number of pages4
JournalAIDS (London, England)
Volume21
Issue number18
DOIs
Publication statusPublished - Dec 2007
Externally publishedYes

Keywords

  • Adult
  • Cross-Sectional Studies
  • Female
  • HIV Infections/complications
  • Hepatitis B, Chronic/complications
  • Hepatitis C, Chronic/complications
  • Hepatitis D, Chronic/complications
  • Hepatitis, Viral, Human/complications
  • Humans
  • Liver Cirrhosis/virology
  • Male
  • Middle Aged
  • Severity of Illness Index

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