TY - JOUR
T1 - Impact of delivery room resuscitation on outcomes up to 18 months in very low birth weight infants
AU - DeMauro, Sara B.
AU - Roberts, Robin S.
AU - Davis, Peter
AU - Alvaro, Ruben
AU - Bairam, Aida
AU - Schmidt, Barbara
AU - AUTHOR GROUP
AU - Schmidt, B.
AU - D'Ilario, J.
AU - Cairnie, J.
AU - Dix, J.
AU - Adams, B.
AU - Davis, P.
AU - Doyle, L.
AU - Faber, B.
AU - Callanan, K.
AU - Davis, N.
AU - Duff, J.
AU - Ford, G.
AU - Asztalos, E.
AU - Golec, L.
AU - Lacy, M.
AU - Hohn, D.
AU - Haslam, R.
AU - Barnett, C.
AU - Goodchild, L.
AU - Lontis, R.
AU - Fraser, S.
AU - Keng, J.
AU - Saunders, K.
AU - Opie, G.
AU - Kelly, E.
AU - Bairam, A.
AU - Ferland, S.
AU - Laperriere, L.
AU - Bélanger, S.
AU - St-Amand, P.
AU - Blayney, M.
AU - Davis, D.
AU - Frank, J.
AU - Lemyre, B.
AU - Solimano, A.
AU - Singh, A.
AU - Chalmers, M.
AU - Ramsay, K.
AU - Synnes, A.
AU - Whitfield, M.
AU - Rogers, M.
AU - Offringa, M.
AU - Kok, J.
AU - van Wassenaer, A.
PY - 2011
Y1 - 2011
N2 - To examine the relationships between intensity of delivery room resuscitation and short- and long-term outcomes of very low birth weight infants enrolled in the Caffeine for Apnea of Prematurity (CAP) Trial. The CAP Trial enrolled 2006 infants with birthweights between 500 and 1250 g who were eligible for caffeine therapy. All levels of delivery room resuscitation were recorded in study participants. We divided infants in 4 groups of increasing intensity of resuscitation: minimal, n = 343; bag-mask ventilation, n = 372; endotracheal intubation, n = 1205; and cardiopulmonary resuscitation (chest compressions/epinephrine), n = 86. We used multivariable logistic regression models to compare outcomes across the 4 groups. The observed rates of death or disability, death, cerebral palsy, cognitive deficit, and hearing loss at 18 months increased with higher levels of resuscitation. Risk of bronchopulmonary dysplasia, severe retinopathy of prematurity, and brain injury also increased with higher levels of resuscitation. Adjustment for prognostic variables reduced the differences between the groups for most outcomes. Only the adjusted rates of bronchopulmonary dysplasia and severe retinopathy remained significantly higher after more intense resuscitation. In CAP Trial participants, the risk of death or neurodevelopmental disability at 18 months did not increase substantially with increasing intensity of delivery room resuscitation
AB - To examine the relationships between intensity of delivery room resuscitation and short- and long-term outcomes of very low birth weight infants enrolled in the Caffeine for Apnea of Prematurity (CAP) Trial. The CAP Trial enrolled 2006 infants with birthweights between 500 and 1250 g who were eligible for caffeine therapy. All levels of delivery room resuscitation were recorded in study participants. We divided infants in 4 groups of increasing intensity of resuscitation: minimal, n = 343; bag-mask ventilation, n = 372; endotracheal intubation, n = 1205; and cardiopulmonary resuscitation (chest compressions/epinephrine), n = 86. We used multivariable logistic regression models to compare outcomes across the 4 groups. The observed rates of death or disability, death, cerebral palsy, cognitive deficit, and hearing loss at 18 months increased with higher levels of resuscitation. Risk of bronchopulmonary dysplasia, severe retinopathy of prematurity, and brain injury also increased with higher levels of resuscitation. Adjustment for prognostic variables reduced the differences between the groups for most outcomes. Only the adjusted rates of bronchopulmonary dysplasia and severe retinopathy remained significantly higher after more intense resuscitation. In CAP Trial participants, the risk of death or neurodevelopmental disability at 18 months did not increase substantially with increasing intensity of delivery room resuscitation
U2 - https://doi.org/10.1016/j.jpeds.2011.03.025
DO - https://doi.org/10.1016/j.jpeds.2011.03.025
M3 - Article
C2 - 21592510
SN - 0022-3476
VL - 159
SP - 546-50.e1
JO - Journal of pediatrics
JF - Journal of pediatrics
IS - 4
ER -