TY - JOUR
T1 - Impact of fatigue on health-related quality of life in patients with Parkinson's disease: a prospective study
AU - Elbers, R.G.
AU - van Wegen, E.E.H.
AU - Verhoef, J.
AU - Kwakkel, G.
PY - 2014
Y1 - 2014
N2 - Objective: To investigate the longitudinal association between the impact of fatigue and health-related quality of life and to determine if potential confounders distorted this association. Design: Baseline, 3-, 6- and 12-week assessments of a randomized clinical trial were used. Setting: Outpatient rehabilitation centre. Subjects: Patients with idiopathic Parkinsons disease. Methods: Quality of life was assessed with the Parkinsons Disease Questionnaire-39 and the Multidimensional Fatigue Inventory was used to assess fatigue. Time-independent and time-dependent factors were investigated for their bivariate association with quality of life by applying random coefficient analysis. Candidate confounders were successively added to the longitudinal association model to determine if the relationship between quality of life and fatigue was distorted. A change beyond 15% of found regression coefficient of the Multidimensional Fatigue Inventory was considered significant. Results: One hundred and fifty-three patients were included. Impact of fatigue was significantly associated with poorer quality of life (β = 0.24, 95% confidence interval = 0.18 to 0.30). This association was significantly distorted by depression (30.0%) and anxiety (24.1%). No distortion was found for other factors. After controlling for confounders, fatigue remained significantly associated with quality of life (β = 0.12, 95% confidence interval = 0.06 to 0.18, r
AB - Objective: To investigate the longitudinal association between the impact of fatigue and health-related quality of life and to determine if potential confounders distorted this association. Design: Baseline, 3-, 6- and 12-week assessments of a randomized clinical trial were used. Setting: Outpatient rehabilitation centre. Subjects: Patients with idiopathic Parkinsons disease. Methods: Quality of life was assessed with the Parkinsons Disease Questionnaire-39 and the Multidimensional Fatigue Inventory was used to assess fatigue. Time-independent and time-dependent factors were investigated for their bivariate association with quality of life by applying random coefficient analysis. Candidate confounders were successively added to the longitudinal association model to determine if the relationship between quality of life and fatigue was distorted. A change beyond 15% of found regression coefficient of the Multidimensional Fatigue Inventory was considered significant. Results: One hundred and fifty-three patients were included. Impact of fatigue was significantly associated with poorer quality of life (β = 0.24, 95% confidence interval = 0.18 to 0.30). This association was significantly distorted by depression (30.0%) and anxiety (24.1%). No distortion was found for other factors. After controlling for confounders, fatigue remained significantly associated with quality of life (β = 0.12, 95% confidence interval = 0.06 to 0.18, r
U2 - https://doi.org/10.1177/0269215513503355
DO - https://doi.org/10.1177/0269215513503355
M3 - Article
C2 - 24113725
SN - 0269-2155
VL - 28
SP - 300
EP - 311
JO - Clinical rehabilitation
JF - Clinical rehabilitation
IS - 3
ER -
