TY - JOUR
T1 - Impact of open and minimally invasive resection of symptomatic solid benign liver tumours on symptoms and quality of life
T2 - a systematic review
AU - Dutch Benign Liver Tumour Group
AU - van Rosmalen, Belle V
AU - de Graeff, Jan Jaap
AU - van der Poel, Marcel J
AU - de Man, Ilja E
AU - Besselink, Marc
AU - Abu Hilal, Mohammad
AU - Busch, Olivier R
AU - Verheij, Joanne
AU - van Gulik, Thomas M
N1 - Copyright © 2019 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - BACKGROUND: The value of open and minimally invasive liver resection for symptomatic solid benign liver tumours (BLT) such as hepatocellular adenoma, focal nodular hyperplasia and haemangioma is being debated. A systematic review on symptom relief, quality of life (QoL) and surgical outcome after both open and minimally invasive surgery for solid BLT is currently lacking.METHODS: A systematic search in PubMed and EMBASE was performed according to the PRISMA guidelines (January 1985-April 2018). Articles reporting pre-and postoperative symptoms or QoL in patients undergoing open or minimally surgery for BLT were evaluated. Methodological quality was assessed using the MINORS tool.RESULTS: Forty-two studies were included with 4061 patients undergoing surgery for BLT, 3536 (87%) open and 525 (13%) laparoscopic resections. Randomized and propensity-matched studies were lacking. Symptoms were the indication for resection in 56% of the patients. After a weighted mean of 28.5 months follow-up after surgery, symptoms were relieved in 82% of symptomatic patients. Validated QoL tools were used in eight studies, of which two found significant better QoL scores following laparoscopic compared to open surgery.DISCUSSION: Resection of symptomatic BLT seems safe and relieves symptoms in the vast majority of selected patients. Comparative studies are needed before more firm conclusions can be drawn.
AB - BACKGROUND: The value of open and minimally invasive liver resection for symptomatic solid benign liver tumours (BLT) such as hepatocellular adenoma, focal nodular hyperplasia and haemangioma is being debated. A systematic review on symptom relief, quality of life (QoL) and surgical outcome after both open and minimally invasive surgery for solid BLT is currently lacking.METHODS: A systematic search in PubMed and EMBASE was performed according to the PRISMA guidelines (January 1985-April 2018). Articles reporting pre-and postoperative symptoms or QoL in patients undergoing open or minimally surgery for BLT were evaluated. Methodological quality was assessed using the MINORS tool.RESULTS: Forty-two studies were included with 4061 patients undergoing surgery for BLT, 3536 (87%) open and 525 (13%) laparoscopic resections. Randomized and propensity-matched studies were lacking. Symptoms were the indication for resection in 56% of the patients. After a weighted mean of 28.5 months follow-up after surgery, symptoms were relieved in 82% of symptomatic patients. Validated QoL tools were used in eight studies, of which two found significant better QoL scores following laparoscopic compared to open surgery.DISCUSSION: Resection of symptomatic BLT seems safe and relieves symptoms in the vast majority of selected patients. Comparative studies are needed before more firm conclusions can be drawn.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063270235&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30926331
U2 - https://doi.org/10.1016/j.hpb.2019.02.022
DO - https://doi.org/10.1016/j.hpb.2019.02.022
M3 - Review article
C2 - 30926331
SN - 1365-182X
VL - 21
SP - 1119
EP - 1130
JO - HPB: The official journal of the International Hepato Pancreato Biliary Association
JF - HPB: The official journal of the International Hepato Pancreato Biliary Association
IS - 9
ER -