Impact of percutaneous coronary intervention timing on 5-year outcome in patients with non-ST-segment elevation acute coronary syndromes. The 'wait a day' approach might be safer

Erik F. J. Oosterwerff; N. D. Fagel; T. Slagboom; J. G. P. Tijssen; J. P. Herrman; P. C. Smits; M. J. Suttorp; E. Ronner; G. J. Laarman; M. S. Patterson; G. Amoroso; M. A. Vink; R. J. van der Schaaf; F. W. A. Verheugt; R. K. Riezebos

doi:https://doi.org/10.1007/s12471-016-0803-0

Impact of percutaneous coronary intervention timing on 5-year outcome in patients with non-ST-segment elevation acute coronary syndromes. The 'wait a day' approach might be safer

Erik F. J. Oosterwerff, N. D. Fagel, T. Slagboom, J. G. P. Tijssen, J. P. Herrman, P. C. Smits, M. J. Suttorp, E. Ronner, G. J. Laarman, M. S. Patterson, G. Amoroso, M. A. Vink, R. J. van der Schaaf, F. W. A. Verheugt, R. K. Riezebos

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

Background The OPTIMA trial was a randomised multi-centre trial exploring the influence of the timing of percutaneous coronary intervention (PCI) on patient outcomes in an intermediate to high risk non-ST-elevation acute coronary syndrome (NSTE-ACS) population. In order to decide the best treatment strategy for patients presenting with NSTE-ACS, long-term outcomes are essential. Methods Five-year follow-up data from 133 of the 142 patients could be retrieved (94 %). The primary endpoint was a composite of death and spontaneous myocardial infarction (MI). Spontaneous MI was defined as MI occurring more than 30 days after randomisation. Secondary endpoints were the individual outcomes of death, spontaneous MI or re-PCI. Results No significant difference with respect to the primary endpoint was observed (17.8 vs. 10.1 %; HR 1.55, 95 % CI: 0.73-4.22, p = 0.21). There was no significant difference in mortality rate. However, spontaneous MI was significantly more common in the group receiving immediate PCI (11.0 vs. 1.4 %; HR 4.46, 95 % CI: 1.21-16.50, p = 0.02). We did not find a significant difference between the groups with respect to re-PCI rate. Conclusion There was no difference in the composite of death and spontaneous MI. The trial suggests an increased long-term risk of spontaneous MI for patients treated with immediate PCI

Original language	English
Pages (from-to)	173-180
Journal	Netherlands heart journal
Volume	24
Issue number	3
DOIs	https://doi.org/10.1007/s12471-016-0803-0
Publication status	Published - 2016

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https://doi.org/10.1007/s12471-016-0803-0

Cite this

Oosterwerff, E. F. J., Fagel, N. D., Slagboom, T., Tijssen, J. G. P., Herrman, J. P., Smits, P. C., Suttorp, M. J., Ronner, E., Laarman, G. J., Patterson, M. S., Amoroso, G., Vink, M. A., van der Schaaf, R. J., Verheugt, F. W. A., & Riezebos, R. K. (2016). Impact of percutaneous coronary intervention timing on 5-year outcome in patients with non-ST-segment elevation acute coronary syndromes. The 'wait a day' approach might be safer. Netherlands heart journal, 24(3), 173-180. https://doi.org/10.1007/s12471-016-0803-0

@article{822680fbabee41e7ba36e17d73aa3298,

title = "Impact of percutaneous coronary intervention timing on 5-year outcome in patients with non-ST-segment elevation acute coronary syndromes. The 'wait a day' approach might be safer",

abstract = "Background The OPTIMA trial was a randomised multi-centre trial exploring the influence of the timing of percutaneous coronary intervention (PCI) on patient outcomes in an intermediate to high risk non-ST-elevation acute coronary syndrome (NSTE-ACS) population. In order to decide the best treatment strategy for patients presenting with NSTE-ACS, long-term outcomes are essential. Methods Five-year follow-up data from 133 of the 142 patients could be retrieved (94 %). The primary endpoint was a composite of death and spontaneous myocardial infarction (MI). Spontaneous MI was defined as MI occurring more than 30 days after randomisation. Secondary endpoints were the individual outcomes of death, spontaneous MI or re-PCI. Results No significant difference with respect to the primary endpoint was observed (17.8 vs. 10.1 %; HR 1.55, 95 % CI: 0.73-4.22, p = 0.21). There was no significant difference in mortality rate. However, spontaneous MI was significantly more common in the group receiving immediate PCI (11.0 vs. 1.4 %; HR 4.46, 95 % CI: 1.21-16.50, p = 0.02). We did not find a significant difference between the groups with respect to re-PCI rate. Conclusion There was no difference in the composite of death and spontaneous MI. The trial suggests an increased long-term risk of spontaneous MI for patients treated with immediate PCI",

author = "Oosterwerff, {Erik F. J.} and Fagel, {N. D.} and T. Slagboom and Tijssen, {J. G. P.} and Herrman, {J. P.} and Smits, {P. C.} and Suttorp, {M. J.} and E. Ronner and Laarman, {G. J.} and Patterson, {M. S.} and G. Amoroso and Vink, {M. A.} and {van der Schaaf}, {R. J.} and Verheugt, {F. W. A.} and Riezebos, {R. K.}",

year = "2016",

doi = "https://doi.org/10.1007/s12471-016-0803-0",

language = "English",

volume = "24",

pages = "173--180",

journal = "Netherlands heart journal",

issn = "1568-5888",

publisher = "Bohn Stafleu van Loghum",

number = "3",

}

Oosterwerff, EFJ, Fagel, ND, Slagboom, T, Tijssen, JGP, Herrman, JP, Smits, PC, Suttorp, MJ, Ronner, E, Laarman, GJ, Patterson, MS, Amoroso, G, Vink, MA, van der Schaaf, RJ, Verheugt, FWA & Riezebos, RK 2016, 'Impact of percutaneous coronary intervention timing on 5-year outcome in patients with non-ST-segment elevation acute coronary syndromes. The 'wait a day' approach might be safer', Netherlands heart journal, vol. 24, no. 3, pp. 173-180. https://doi.org/10.1007/s12471-016-0803-0

Impact of percutaneous coronary intervention timing on 5-year outcome in patients with non-ST-segment elevation acute coronary syndromes. The 'wait a day' approach might be safer. / Oosterwerff, Erik F. J.; Fagel, N. D.; Slagboom, T. et al.
In: Netherlands heart journal, Vol. 24, No. 3, 2016, p. 173-180.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Impact of percutaneous coronary intervention timing on 5-year outcome in patients with non-ST-segment elevation acute coronary syndromes. The 'wait a day' approach might be safer

AU - Oosterwerff, Erik F. J.

AU - Fagel, N. D.

AU - Slagboom, T.

AU - Tijssen, J. G. P.

AU - Herrman, J. P.

AU - Smits, P. C.

AU - Suttorp, M. J.

AU - Ronner, E.

AU - Laarman, G. J.

AU - Patterson, M. S.

AU - Amoroso, G.

AU - Vink, M. A.

AU - van der Schaaf, R. J.

AU - Verheugt, F. W. A.

AU - Riezebos, R. K.

PY - 2016

Y1 - 2016

N2 - Background The OPTIMA trial was a randomised multi-centre trial exploring the influence of the timing of percutaneous coronary intervention (PCI) on patient outcomes in an intermediate to high risk non-ST-elevation acute coronary syndrome (NSTE-ACS) population. In order to decide the best treatment strategy for patients presenting with NSTE-ACS, long-term outcomes are essential. Methods Five-year follow-up data from 133 of the 142 patients could be retrieved (94 %). The primary endpoint was a composite of death and spontaneous myocardial infarction (MI). Spontaneous MI was defined as MI occurring more than 30 days after randomisation. Secondary endpoints were the individual outcomes of death, spontaneous MI or re-PCI. Results No significant difference with respect to the primary endpoint was observed (17.8 vs. 10.1 %; HR 1.55, 95 % CI: 0.73-4.22, p = 0.21). There was no significant difference in mortality rate. However, spontaneous MI was significantly more common in the group receiving immediate PCI (11.0 vs. 1.4 %; HR 4.46, 95 % CI: 1.21-16.50, p = 0.02). We did not find a significant difference between the groups with respect to re-PCI rate. Conclusion There was no difference in the composite of death and spontaneous MI. The trial suggests an increased long-term risk of spontaneous MI for patients treated with immediate PCI

AB - Background The OPTIMA trial was a randomised multi-centre trial exploring the influence of the timing of percutaneous coronary intervention (PCI) on patient outcomes in an intermediate to high risk non-ST-elevation acute coronary syndrome (NSTE-ACS) population. In order to decide the best treatment strategy for patients presenting with NSTE-ACS, long-term outcomes are essential. Methods Five-year follow-up data from 133 of the 142 patients could be retrieved (94 %). The primary endpoint was a composite of death and spontaneous myocardial infarction (MI). Spontaneous MI was defined as MI occurring more than 30 days after randomisation. Secondary endpoints were the individual outcomes of death, spontaneous MI or re-PCI. Results No significant difference with respect to the primary endpoint was observed (17.8 vs. 10.1 %; HR 1.55, 95 % CI: 0.73-4.22, p = 0.21). There was no significant difference in mortality rate. However, spontaneous MI was significantly more common in the group receiving immediate PCI (11.0 vs. 1.4 %; HR 4.46, 95 % CI: 1.21-16.50, p = 0.02). We did not find a significant difference between the groups with respect to re-PCI rate. Conclusion There was no difference in the composite of death and spontaneous MI. The trial suggests an increased long-term risk of spontaneous MI for patients treated with immediate PCI

U2 - https://doi.org/10.1007/s12471-016-0803-0

DO - https://doi.org/10.1007/s12471-016-0803-0

M3 - Article

C2 - 26860709

SN - 1568-5888

VL - 24

SP - 173

EP - 180

JO - Netherlands heart journal

JF - Netherlands heart journal

IS - 3

ER -