TY - JOUR
T1 - Impact of protein glycosylation on lipoprotein metabolism and atherosclerosis
AU - Pirillo, Angela
AU - Svecla, Monika
AU - Catapano, Alberico Luigi
AU - Holleboom, Adriaan G.
AU - Norata, Giuseppe Danilo
N1 - Publisher Copyright: © 2020 Published on behalf of the European Society of Cardiology. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Protein glycosylation is a post-translational modification consisting in the enzymatic attachment of carbohydrate chains to specific residues of the protein sequence. Several types of glycosylation have been described, with N-glycosylation and O-glycosylation being the most common types impacting on crucial biological processes, such as protein synthesis, trafficking, localization, and function. Genetic defects in genes involved in protein glycosylation may result in altered production and activity of several proteins, with a broad range of clinical manifestations, including dyslipidaemia and atherosclerosis. A large number of apolipoproteins, lipoprotein receptors, and other proteins involved in lipoprotein metabolism are glycosylated, and alterations in their glycosylation profile are associated with changes in their expression and/or function. Rare genetic diseases and population genetics have provided additional information linking protein glycosylation to the regulation of lipoprotein metabolism.
AB - Protein glycosylation is a post-translational modification consisting in the enzymatic attachment of carbohydrate chains to specific residues of the protein sequence. Several types of glycosylation have been described, with N-glycosylation and O-glycosylation being the most common types impacting on crucial biological processes, such as protein synthesis, trafficking, localization, and function. Genetic defects in genes involved in protein glycosylation may result in altered production and activity of several proteins, with a broad range of clinical manifestations, including dyslipidaemia and atherosclerosis. A large number of apolipoproteins, lipoprotein receptors, and other proteins involved in lipoprotein metabolism are glycosylated, and alterations in their glycosylation profile are associated with changes in their expression and/or function. Rare genetic diseases and population genetics have provided additional information linking protein glycosylation to the regulation of lipoprotein metabolism.
KW - Atherosclerosis
KW - Dyslipidaemias
KW - Glycosylation
UR - http://www.scopus.com/inward/record.url?scp=85103474262&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/cvr/cvaa252
DO - https://doi.org/10.1093/cvr/cvaa252
M3 - Review article
C2 - 32886765
SN - 0008-6363
VL - 117
SP - 1033
EP - 1045
JO - Cardiovascular research
JF - Cardiovascular research
IS - 4
ER -