TY - JOUR
T1 - Impact of quality items on study outcome
T2 - Treatments in acute lateral ankle sprains
AU - Verhagen, Arianne P.
AU - De Bie, Robert A.
AU - Lenssen, Anton F.
AU - De Vet, Henrica C.W.
AU - Kessels, Alphons G.H.
AU - Boers, Maarten
AU - Van Den Brandt, Piet A.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Objective: This study investigates the influence of different aspects of methodologic quality on the conclusions of a systematic review concerning treatments of acute lateral ankle sprain Method: A data set of a systematic review of 44 trials was used, of which 22 trials could be included in this study Quality assessment of the individual studies was performed using the Delphi list. We calculated effect sizes of the main outcome measure in each study in order to evaluate the relationship between overall quality scores and outcome. Next, we investigated the impact of design attributes on pooled effect sizes by subgroup analysis Results: The quality of most studies (82%) was low, only 4 of 22 trials were of high quality. Studies with proper randomization and blinding procedure produce a slightly higher (not statistically significant) effect estimate compared to the other studies Conclusion: Previous research has suggested that methodologically poorly designed studies tend to over-estimate the effect estimate. Our study does not confirm these conclusions.
AB - Objective: This study investigates the influence of different aspects of methodologic quality on the conclusions of a systematic review concerning treatments of acute lateral ankle sprain Method: A data set of a systematic review of 44 trials was used, of which 22 trials could be included in this study Quality assessment of the individual studies was performed using the Delphi list. We calculated effect sizes of the main outcome measure in each study in order to evaluate the relationship between overall quality scores and outcome. Next, we investigated the impact of design attributes on pooled effect sizes by subgroup analysis Results: The quality of most studies (82%) was low, only 4 of 22 trials were of high quality. Studies with proper randomization and blinding procedure produce a slightly higher (not statistically significant) effect estimate compared to the other studies Conclusion: Previous research has suggested that methodologically poorly designed studies tend to over-estimate the effect estimate. Our study does not confirm these conclusions.
KW - Blinding
KW - Effect sizes
KW - Methodology
KW - Randomization
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=0033636248&partnerID=8YFLogxK
U2 - https://doi.org/10.1017/S0266462300103174
DO - https://doi.org/10.1017/S0266462300103174
M3 - Article
SN - 0266-4623
VL - 16
SP - 1136
EP - 1146
JO - International Journal of Technology Assessment in Health Care
JF - International Journal of Technology Assessment in Health Care
IS - 4
ER -