TY - JOUR
T1 - Impact of structural modifications of IgG antibodies on effector functions
AU - Damelang, Timon
AU - Brinkhaus, Maximilian
AU - van Osch, Thijs L. J.
AU - Schuurman, Janine
AU - Labrijn, Aran F.
AU - Rispens, Theo
AU - Vidarsson, Gestur
PY - 2023
Y1 - 2023
N2 - Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system, binding to and neutralizing pathogens and other foreign substances. Recent advances in molecular antibody biology and structural protein engineering enabled the modification of IgG antibodies to enhance their therapeutic potential. This review summarizes recent progress in both natural and engineered structural modifications of IgG antibodies, including allotypic variation, glycosylation, Fc engineering, and Fc gamma receptor binding optimization. We discuss the functional consequences of these modifications to highlight their potential for therapeutical applications.
AB - Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system, binding to and neutralizing pathogens and other foreign substances. Recent advances in molecular antibody biology and structural protein engineering enabled the modification of IgG antibodies to enhance their therapeutic potential. This review summarizes recent progress in both natural and engineered structural modifications of IgG antibodies, including allotypic variation, glycosylation, Fc engineering, and Fc gamma receptor binding optimization. We discuss the functional consequences of these modifications to highlight their potential for therapeutical applications.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85182623453&origin=inward
U2 - https://doi.org/10.3389/fimmu.2023.1304365
DO - https://doi.org/10.3389/fimmu.2023.1304365
M3 - Review article
C2 - 38259472
SN - 1664-3224
VL - 14
JO - Frontiers in immunology
JF - Frontiers in immunology
M1 - 1304365
ER -