TY - JOUR
T1 - Impact of the COVID-19 pandemic on prevalence of highly resistant microorganisms in hospitalised patients in the Netherlands, March 2020 to August 2022
AU - on behalf of the study collaborators ISIS-AR study group
AU - der Kuil, Wieke Altorf Van
AU - Wielders, Cornelia C.H.
AU - Zwittink, Romy D.
AU - de Greeff, Sabine C.
AU - Dongelmans, Dave A.
AU - Kuijper, Ed J.
AU - Notermans, Daan W.
AU - Schoffelen, Annelot F.
N1 - Funding Information: The national AMR surveillance system (ISIS-AR) is supported by the Dutch Ministry of Health. The NICE registry is funded by participation fees paid by each participating hospital. Publisher Copyright: © 2023 European Centre for Disease Prevention and Control (ECDC). All rights reserved.
PY - 2023/12/14
Y1 - 2023/12/14
N2 - Background: The COVID-19 pandemic resulted in adaptation in infection control measures, increased patient transfer, high occupancy of intensive cares, downscaling of non-urgent medical procedures and decreased travelling. Aim: To gain insight in the influence of these changes on antimicrobial resistance (AMR) prevalence in the Netherlands, a country with a low AMR prevalence, we estimated changes in demographics and prevalence of six highly resistant microorganisms (HRMO) in hospitalised patients in the Netherlands during COVID-19 waves (March–June 2020, October 2020–June 2021, October 2021–May 2022 and June–August 2022) and interwaves (July–September 2020 and July–September 2021) compared with pre-COVID-19 (March 2019–February 2020). Methods: We investigated data on routine bacteriology cultures of hospitalised patients, obtained from 37 clinical microbiological laboratories participating in the national AMR surveillance. Demographic characteristics and HRMO prevalence were calculated as proportions and rates per 10,000 hospital admissions. Results: Although no significant persistent changes in HRMO prevalence were detected, some relevant non-significant patterns were recognised in intensive care units. Compared with pre-COVID-19 we found a tendency towards higher prevalence of meticillin-resistant Staphylococcus aureus during waves and lower prevalence of multidrug-resistant Pseudomonas aeruginosa during interwaves. Additionally, during the first three waves, we observed significantly higher proportions and rates of cultures with Enterococcus faecium (pooled10% vs 6% and 240 vs 120 per 10,000 admissions) and coagulase-negative Staphylococci (pooled21% vs 14% and 500 vs 252 per 10,000 admissions) compared with pre-COVID-19. Conclusion: We observed no substantial changes in HRMO prevalence in hospitalised patients during the COVID-19 pandemic.
AB - Background: The COVID-19 pandemic resulted in adaptation in infection control measures, increased patient transfer, high occupancy of intensive cares, downscaling of non-urgent medical procedures and decreased travelling. Aim: To gain insight in the influence of these changes on antimicrobial resistance (AMR) prevalence in the Netherlands, a country with a low AMR prevalence, we estimated changes in demographics and prevalence of six highly resistant microorganisms (HRMO) in hospitalised patients in the Netherlands during COVID-19 waves (March–June 2020, October 2020–June 2021, October 2021–May 2022 and June–August 2022) and interwaves (July–September 2020 and July–September 2021) compared with pre-COVID-19 (March 2019–February 2020). Methods: We investigated data on routine bacteriology cultures of hospitalised patients, obtained from 37 clinical microbiological laboratories participating in the national AMR surveillance. Demographic characteristics and HRMO prevalence were calculated as proportions and rates per 10,000 hospital admissions. Results: Although no significant persistent changes in HRMO prevalence were detected, some relevant non-significant patterns were recognised in intensive care units. Compared with pre-COVID-19 we found a tendency towards higher prevalence of meticillin-resistant Staphylococcus aureus during waves and lower prevalence of multidrug-resistant Pseudomonas aeruginosa during interwaves. Additionally, during the first three waves, we observed significantly higher proportions and rates of cultures with Enterococcus faecium (pooled10% vs 6% and 240 vs 120 per 10,000 admissions) and coagulase-negative Staphylococci (pooled21% vs 14% and 500 vs 252 per 10,000 admissions) compared with pre-COVID-19. Conclusion: We observed no substantial changes in HRMO prevalence in hospitalised patients during the COVID-19 pandemic.
UR - http://www.scopus.com/inward/record.url?scp=85179771983&partnerID=8YFLogxK
U2 - https://doi.org/10.2807/1560-7917.ES.2023.28.50.2300152
DO - https://doi.org/10.2807/1560-7917.ES.2023.28.50.2300152
M3 - Article
C2 - 38099348
SN - 1025-496X
VL - 28
JO - Eurosurveillance
JF - Eurosurveillance
IS - 50
M1 - 2300152
ER -