TY - JOUR
T1 - Impaired cerebral autoregulation in patients with malignant hypertension
AU - Immink, Rogier V.
AU - van den Born, Bert-Jan H.
AU - van Montfrans, Gert A.
AU - Koopmans, Richard P.
AU - Karemaker, John M.
AU - van Lieshout, Johannes J.
PY - 2004
Y1 - 2004
N2 - Background-In patients with a malignant hypertension, immediate parenteral treatment with blood pressure-lowering agents such as intravenous sodium nitroprusside (SNP) is indicated. In this study, we evaluated static and dynamic cerebral autoregulation (CA) during acute blood pressure lowering with SNP in these patients. Methods and Results-In 8 patients with mean arterial pressure (MAP) >140 mm Hg and grade III or IV hypertensive retinopathy at hospital admission, middle cerebral artery blood velocity (MCA V) and blood pressure were monitored. Dynamic CA was expressed as the 0.1-Hz MCA V-mean to MAP phase lead and static CA as the MCA V-mean to MAP relationship during SNP treatment. Eight normotensive subjects served as a reference group. In the patients, the MCA V-mean to MAP phase lead was lower (30+/-8degrees versus 5+/-5degrees, mean+/-SEM; P <0.05), whereas the transfer gain tended to be higher. During SNP treatment, target MAP was reached within 90 minutes in all patients. The MCA V-mean decrease was 22&PLUSMN;4%, along with a 27&PLUSMN;3% reduction in MAP (from 166&PLUSMN;4 to 121&PLUSMN;6 mm Hg; P <0.05) in a linear fashion (averaged slope, 0.82+/-0.15% cm.s(-1).% mmHg(-1); r=0.70+/-0.07). Conclusions-In patients with malignant hypertension, dynamic CA is impaired. An MCA V-mean plateau was not detected during the whole SNP treatment, indicating loss of static CA as well. This study showed that during the whole rapid reduction in blood pressure with SNP, MCA V-mean decreases almost one on one with MAP
AB - Background-In patients with a malignant hypertension, immediate parenteral treatment with blood pressure-lowering agents such as intravenous sodium nitroprusside (SNP) is indicated. In this study, we evaluated static and dynamic cerebral autoregulation (CA) during acute blood pressure lowering with SNP in these patients. Methods and Results-In 8 patients with mean arterial pressure (MAP) >140 mm Hg and grade III or IV hypertensive retinopathy at hospital admission, middle cerebral artery blood velocity (MCA V) and blood pressure were monitored. Dynamic CA was expressed as the 0.1-Hz MCA V-mean to MAP phase lead and static CA as the MCA V-mean to MAP relationship during SNP treatment. Eight normotensive subjects served as a reference group. In the patients, the MCA V-mean to MAP phase lead was lower (30+/-8degrees versus 5+/-5degrees, mean+/-SEM; P <0.05), whereas the transfer gain tended to be higher. During SNP treatment, target MAP was reached within 90 minutes in all patients. The MCA V-mean decrease was 22&PLUSMN;4%, along with a 27&PLUSMN;3% reduction in MAP (from 166&PLUSMN;4 to 121&PLUSMN;6 mm Hg; P <0.05) in a linear fashion (averaged slope, 0.82+/-0.15% cm.s(-1).% mmHg(-1); r=0.70+/-0.07). Conclusions-In patients with malignant hypertension, dynamic CA is impaired. An MCA V-mean plateau was not detected during the whole SNP treatment, indicating loss of static CA as well. This study showed that during the whole rapid reduction in blood pressure with SNP, MCA V-mean decreases almost one on one with MAP
U2 - https://doi.org/10.1161/01.CIR.0000144472.08647.40
DO - https://doi.org/10.1161/01.CIR.0000144472.08647.40
M3 - Article
C2 - 15466625
SN - 0009-7322
VL - 110
SP - 2241
EP - 2245
JO - Circulation
JF - Circulation
IS - 15
ER -