TY - JOUR
T1 - Impaired sustained attention in adult patients with type 1 diabetes is related to diabetes per se
AU - van Dijk, Marieke [Leiden Univ., LUMC]
AU - Donga, Esther
AU - van Schie, Mojca K. M.
AU - Lammers, Gert Jan
AU - van Zwet, Erik W.
AU - Corssmit, Eleonora P. M.
AU - Romijn, Johannes A.
AU - van Dijk, J. Gert
PY - 2014
Y1 - 2014
N2 - BackgroundPatients with type 1 diabetes have altered sleep characteristics and are thought to have deficits in sustained attention. We compared the sustained attention to response task (SART) of patients with type 1 diabetes to that of healthy controls, and related results with sleep characteristics and disease-related factors. MethodsSART was applied in 122 patients and 109 controls. Glucoregulation was assessed by HbA(1c) values and a questionnaire assessing glycaemic history. Clinical parameters were obtained from medical charts. Polyneuropathy was assessed by neurological examination and quantitative sensory testing. Sleep characteristics were assessed with sleep questionnaires. Anxiety and depression scores were assessed by the Hospital Anxiety and Depression Scale. ResultsThe SART reaction time (RT) was significantly longer than in controls (3275 vs. 285 +/- 3ms, p <0.001), although there were no significant differences in error scores. Repeated measurement analyses showed that diabetes per se was associated with prolonged RT (p <0.001) and more commission errors (p=0.010). None of the sleep-related and diabetes-related factors were significantly associated with these SART parameters. ConclusionsPatients with type 1 diabetes had impaired sustained attention, which was associated with diabetes per se but not with disturbed sleep characteristics. Copyright (c) 2013 John Wiley & Sons, Ltd
AB - BackgroundPatients with type 1 diabetes have altered sleep characteristics and are thought to have deficits in sustained attention. We compared the sustained attention to response task (SART) of patients with type 1 diabetes to that of healthy controls, and related results with sleep characteristics and disease-related factors. MethodsSART was applied in 122 patients and 109 controls. Glucoregulation was assessed by HbA(1c) values and a questionnaire assessing glycaemic history. Clinical parameters were obtained from medical charts. Polyneuropathy was assessed by neurological examination and quantitative sensory testing. Sleep characteristics were assessed with sleep questionnaires. Anxiety and depression scores were assessed by the Hospital Anxiety and Depression Scale. ResultsThe SART reaction time (RT) was significantly longer than in controls (3275 vs. 285 +/- 3ms, p <0.001), although there were no significant differences in error scores. Repeated measurement analyses showed that diabetes per se was associated with prolonged RT (p <0.001) and more commission errors (p=0.010). None of the sleep-related and diabetes-related factors were significantly associated with these SART parameters. ConclusionsPatients with type 1 diabetes had impaired sustained attention, which was associated with diabetes per se but not with disturbed sleep characteristics. Copyright (c) 2013 John Wiley & Sons, Ltd
U2 - https://doi.org/10.1002/dmrr.2467
DO - https://doi.org/10.1002/dmrr.2467
M3 - Article
C2 - 24026944
SN - 1520-7552
VL - 30
SP - 132
EP - 139
JO - Diabetes/metabolism research and reviews
JF - Diabetes/metabolism research and reviews
IS - 2
ER -