Implementing genome-wide non-invasive prenatal testing in a national prenatal screening program

KRM van der Meij

Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

Abstract

The introduction of non-invasive prenatal testing (NIPT) as a screening test for the detection of fetal aneuploidies has transformed prenatal screening worldwide. NIPT is a safe and reliable screening method to detect fetal aneuploidies in maternal blood. In April 2017, first-tier NIPT was implemented in the Netherlands for all pregnant women as part of the TRIDENT-2 study initiated by the Dutch NIPT consortium. This thesis aimed to evaluate the responsible introduction of first-tier NIPT in the Dutch prenatal screening program. The studies in this thesis focus on aspects related to the implementation of NIPT (part I) and the perspectives of pregnant women (part II).
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Vrije Universiteit Amsterdam
Supervisors/Advisors
  • Henneman, Lidewij, Supervisor
  • Cornel, Martina, Supervisor
  • Sistermans, Erik, Supervisor
  • Weiss, Janneke, Supervisor
  • Cornel, M.C., Supervisor
  • Sistermans, E.A., Co-supervisor, External person
  • Weiss, Marjan, Co-supervisor, External person
Award date23 Nov 2022
Place of PublicationAmsterdam
Publisher
Print ISBNs9789464585605
Publication statusPublished - 23 Nov 2022

Keywords

  • NIPT
  • first-tier test
  • genome-wide
  • implementation
  • prenatal screening
  • women's perspectives

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-being

Access to Document

Cite this