Implications of a positive sentinel node in oral squamous cell carcinoma

B.A.S. Gurney; C. Schilling; V. Putcha; L.W. Alkureishi; A.J. Alvarez; V. Bakholdt; L. Barbier Herrero; L. Barzan; A. Bilde; E. Bloemena; C.C. Salces; P.D. Palma; R. de Bree; D. Dequanter; G. Dolivet; D. Donner; G.B. Flach; M. Fresno; C. Grandi; S. Haerle; G.F. Huber; K. Hunter; G. Lawson; A. Leroux; P.H. Lothaire; G. Mamelle; R. Mastronicola; E.W. Odell; M.J. O'Doherty; T. Poli; S. Rahimi; G.L. Ross; J.S. Zuazua; S. Santini; L. Sebbesen; T. Shoaib; P. Sloan; J.A. Sorensen; D.S. Soutar; M.H. Therkildsen; M.G. Vigili; P.M. Villarreal; C. von Buchwald; J.A. Werner; S. Wiegand; M. McGurk

doi:https://doi.org/10.1002/hed.21973

Implications of a positive sentinel node in oral squamous cell carcinoma

B.A.S. Gurney, C. Schilling, V. Putcha, L.W. Alkureishi, A.J. Alvarez, V. Bakholdt, L. Barbier Herrero, L. Barzan, A. Bilde, E. Bloemena, C.C. Salces, P.D. Palma, R. de Bree, D. Dequanter, G. Dolivet, D. Donner, G.B. Flach, M. Fresno, C. Grandi, S. HaerleG.F. Huber, K. Hunter, G. Lawson, A. Leroux, P.H. Lothaire, G. Mamelle, R. Mastronicola, E.W. Odell, M.J. O'Doherty, T. Poli, S. Rahimi, G.L. Ross, J.S. Zuazua, S. Santini, L. Sebbesen, T. Shoaib, P. Sloan, J.A. Sorensen, D.S. Soutar, M.H. Therkildsen, M.G. Vigili, P.M. Villarreal, C. von Buchwald, J.A. Werner, S. Wiegand, M. McGurk

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

Background
The role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.

Methods
In all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan-Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck.

Results
A total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome.

Conclusions
The results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans.

Original language	English
Pages (from-to)	1580-1585
Journal	Head & neck
Volume	34
Issue number	11
DOIs	https://doi.org/10.1002/hed.21973
Publication status	Published - 2012

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Cite this

Gurney, B. A. S., Schilling, C., Putcha, V., Alkureishi, L. W., Alvarez, A. J., Bakholdt, V., Barbier Herrero, L., Barzan, L., Bilde, A., Bloemena, E., Salces, C. C., Palma, P. D., de Bree, R., Dequanter, D., Dolivet, G., Donner, D., Flach, G. B., Fresno, M., Grandi, C., ... McGurk, M. (2012). Implications of a positive sentinel node in oral squamous cell carcinoma. Head & neck, 34(11), 1580-1585. https://doi.org/10.1002/hed.21973

@article{98fbc728b82d400f9128ad0da203d9a8,

title = "Implications of a positive sentinel node in oral squamous cell carcinoma",

abstract = "BackgroundThe role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.MethodsIn all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan-Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck.ResultsA total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome.ConclusionsThe results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans.",

author = "B.A.S. Gurney and C. Schilling and V. Putcha and L.W. Alkureishi and A.J. Alvarez and V. Bakholdt and {Barbier Herrero}, L. and L. Barzan and A. Bilde and E. Bloemena and C.C. Salces and P.D. Palma and {de Bree}, R. and D. Dequanter and G. Dolivet and D. Donner and G.B. Flach and M. Fresno and C. Grandi and S. Haerle and G.F. Huber and K. Hunter and G. Lawson and A. Leroux and P.H. Lothaire and G. Mamelle and R. Mastronicola and E.W. Odell and M.J. O'Doherty and T. Poli and S. Rahimi and G.L. Ross and J.S. Zuazua and S. Santini and L. Sebbesen and T. Shoaib and P. Sloan and J.A. Sorensen and D.S. Soutar and M.H. Therkildsen and M.G. Vigili and P.M. Villarreal and {von Buchwald}, C. and J.A. Werner and S. Wiegand and M. McGurk",

year = "2012",

doi = "https://doi.org/10.1002/hed.21973",

language = "English",

volume = "34",

pages = "1580--1585",

journal = "Head & neck",

issn = "1043-3074",

publisher = "John Wiley and Sons Inc.",

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Gurney, BAS, Schilling, C, Putcha, V, Alkureishi, LW, Alvarez, AJ, Bakholdt, V, Barbier Herrero, L, Barzan, L, Bilde, A, Bloemena, E, Salces, CC, Palma, PD, de Bree, R, Dequanter, D, Dolivet, G, Donner, D, Flach, GB, Fresno, M, Grandi, C, Haerle, S, Huber, GF, Hunter, K, Lawson, G, Leroux, A, Lothaire, PH, Mamelle, G, Mastronicola, R, Odell, EW, O'Doherty, MJ, Poli, T, Rahimi, S, Ross, GL, Zuazua, JS, Santini, S, Sebbesen, L, Shoaib, T, Sloan, P, Sorensen, JA, Soutar, DS, Therkildsen, MH, Vigili, MG, Villarreal, PM, von Buchwald, C, Werner, JA, Wiegand, S & McGurk, M 2012, 'Implications of a positive sentinel node in oral squamous cell carcinoma', Head & neck, vol. 34, no. 11, pp. 1580-1585. https://doi.org/10.1002/hed.21973

TY - JOUR

T1 - Implications of a positive sentinel node in oral squamous cell carcinoma

AU - Gurney, B.A.S.

AU - Schilling, C.

AU - Putcha, V.

AU - Alkureishi, L.W.

AU - Alvarez, A.J.

AU - Bakholdt, V.

AU - Barbier Herrero, L.

AU - Barzan, L.

AU - Bilde, A.

AU - Bloemena, E.

AU - Salces, C.C.

AU - Palma, P.D.

AU - de Bree, R.

AU - Dequanter, D.

AU - Dolivet, G.

AU - Donner, D.

AU - Flach, G.B.

AU - Fresno, M.

AU - Grandi, C.

AU - Haerle, S.

AU - Huber, G.F.

AU - Hunter, K.

AU - Lawson, G.

AU - Leroux, A.

AU - Lothaire, P.H.

AU - Mamelle, G.

AU - Mastronicola, R.

AU - Odell, E.W.

AU - O'Doherty, M.J.

AU - Poli, T.

AU - Rahimi, S.

AU - Ross, G.L.

AU - Zuazua, J.S.

AU - Santini, S.

AU - Sebbesen, L.

AU - Shoaib, T.

AU - Sloan, P.

AU - Sorensen, J.A.

AU - Soutar, D.S.

AU - Therkildsen, M.H.

AU - Vigili, M.G.

AU - Villarreal, P.M.

AU - von Buchwald, C.

AU - Werner, J.A.

AU - Wiegand, S.

AU - McGurk, M.

PY - 2012

Y1 - 2012

N2 - BackgroundThe role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.MethodsIn all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan-Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck.ResultsA total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome.ConclusionsThe results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans.

AB - BackgroundThe role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.MethodsIn all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan-Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck.ResultsA total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome.ConclusionsThe results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans.

U2 - https://doi.org/10.1002/hed.21973

DO - https://doi.org/10.1002/hed.21973

M3 - Article

C2 - 22290737

SN - 1043-3074

VL - 34

SP - 1580

EP - 1585

JO - Head & neck

JF - Head & neck

IS - 11

ER -