TY - JOUR
T1 - Implications of differential age distribution of disease-associated meningococcal lineages for vaccine development
AU - Brehony, Carina
AU - Trotter, Caroline L.
AU - Ramsay, Mary E.
AU - Chandra, Manosree
AU - Jolley, Keith A.
AU - van der Ende, Arie
AU - Carion, Françoise
AU - Berthelsen, Lene
AU - Hoffmann, Steen
AU - Harðardóttir, Hjördís
AU - Vazquez, Julio A.
AU - Murphy, Karen
AU - Toropainen, Maija
AU - Caniça, Manuela
AU - Ferreira, Eugenia
AU - Diggle, Mathew
AU - Edwards, Giles F.
AU - Taha, Muhamed-Kheir
AU - Stefanelli, Paola
AU - Kriz, Paula
AU - Gray, Steve J.
AU - Fox, Andrew J.
AU - Jacobsson, Susanne
AU - Claus, Heike
AU - Vogel, Ulrich
AU - Tzanakaki, Georgina
AU - Heuberger, Sigrid
AU - Caugant, Dominique A.
AU - Frosch, Matthias
AU - Maiden, Martin C. J.
PY - 2014
Y1 - 2014
N2 - New vaccines targeting meningococci expressing serogroup B polysaccharide have been developed, with some being licensed in Europe. Coverage depends on the distribution of disease-associated genotypes, which may vary by age. It is well established that a small number of hyperinvasive lineages account for most disease, and these lineages are associated with particular antigens, including vaccine candidates. A collection of 4,048 representative meningococcal disease isolates from 18 European countries, collected over a 3-year period, were characterized by multilocus sequence typing (MLST). Age data were available for 3,147 isolates. The proportions of hyperinvasive lineages, identified as particular clonal complexes (ccs) by MLST, differed among age groups. Subjects <1 year of age experienced lower risk of sequence type 11 (ST-11) cc, ST-32 cc, and ST-269 cc disease and higher risk of disease due to unassigned STs, 1- to 4-year-olds experienced lower risk of ST-11 cc and ST-32 cc disease, 5- to 14-year-olds were less likely to experience ST-11 cc and ST-269 cc disease, and ≥25-year-olds were more likely to experience disease due to less common ccs and unassigned STs. Younger and older subjects were vulnerable to a more diverse set of genotypes, indicating the more clonal nature of genotypes affecting adolescents and young adults. Knowledge of temporal and spatial diversity and the dynamics of meningococcal populations is essential for disease control by vaccines, as coverage is lineage specific. The nonrandom age distribution of hyperinvasive lineages has consequences for the design and implementation of vaccines, as different variants, or perhaps targets, may be required for different age groups
AB - New vaccines targeting meningococci expressing serogroup B polysaccharide have been developed, with some being licensed in Europe. Coverage depends on the distribution of disease-associated genotypes, which may vary by age. It is well established that a small number of hyperinvasive lineages account for most disease, and these lineages are associated with particular antigens, including vaccine candidates. A collection of 4,048 representative meningococcal disease isolates from 18 European countries, collected over a 3-year period, were characterized by multilocus sequence typing (MLST). Age data were available for 3,147 isolates. The proportions of hyperinvasive lineages, identified as particular clonal complexes (ccs) by MLST, differed among age groups. Subjects <1 year of age experienced lower risk of sequence type 11 (ST-11) cc, ST-32 cc, and ST-269 cc disease and higher risk of disease due to unassigned STs, 1- to 4-year-olds experienced lower risk of ST-11 cc and ST-32 cc disease, 5- to 14-year-olds were less likely to experience ST-11 cc and ST-269 cc disease, and ≥25-year-olds were more likely to experience disease due to less common ccs and unassigned STs. Younger and older subjects were vulnerable to a more diverse set of genotypes, indicating the more clonal nature of genotypes affecting adolescents and young adults. Knowledge of temporal and spatial diversity and the dynamics of meningococcal populations is essential for disease control by vaccines, as coverage is lineage specific. The nonrandom age distribution of hyperinvasive lineages has consequences for the design and implementation of vaccines, as different variants, or perhaps targets, may be required for different age groups
U2 - https://doi.org/10.1128/CVI.00133-14
DO - https://doi.org/10.1128/CVI.00133-14
M3 - Article
C2 - 24695776
SN - 1556-6811
VL - 21
SP - 847
EP - 853
JO - Clinical and vaccine immunology
JF - Clinical and vaccine immunology
IS - 6
ER -