TY - JOUR
T1 - Importance of exercise stress testing in evaluation of unexplained cardiac arrest survivor
AU - Bergeman, Auke T.
AU - Robyns, Tomas
AU - Amin, Ahmad S.
AU - Wilde, Arthur A. M.
AU - van der Werf, Christian
N1 - Funding Information: This work was supported by the Netherlands Organisation for Health Research and Development (ZonMw) Priority Medicines for Rare Diseases and Orphan Drugs research programme (grant number 113304045; paid to C. van der Werf), eRare (E-rare 3—Joint Call 2015; paid to A. A. M. Wilde) and the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centres, the Netherlands Organisation for Health Research and Development and the Royal Netherlands Academy of Sciences (PREDICT2; paid to A. A. M. Wilde). Publisher Copyright: © 2023, The Author(s).
PY - 2023/11
Y1 - 2023/11
N2 - Background: In sudden cardiac arrest survivors without an immediately identifiable cause, additional extensive yet individualised testing is required. Methods: We describe 3 survivors of sudden cardiac arrest in whom exercise stress testing was not performed during the initial hospital admission. Results: All 3 patients were incorrectly diagnosed with long QT syndrome based on temporary sudden cardiac arrest–related heart rate–corrected QT interval prolongation, and exercise stress testing was not performed during the initial work-up. When they were subjected to exercise stress testing during follow-up, a delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia (CPVT) was made. As a result, these patients were initially managed inappropriately, and their family members were initially not screened for CPVT. Conclusion: In sudden cardiac arrest survivors without an immediately identifiable cause, omission of exercise stress testing or erroneous interpretation of the results can lead to a delayed or missed diagnosis of CPVT, which may have considerable implications for survivors and their family.
AB - Background: In sudden cardiac arrest survivors without an immediately identifiable cause, additional extensive yet individualised testing is required. Methods: We describe 3 survivors of sudden cardiac arrest in whom exercise stress testing was not performed during the initial hospital admission. Results: All 3 patients were incorrectly diagnosed with long QT syndrome based on temporary sudden cardiac arrest–related heart rate–corrected QT interval prolongation, and exercise stress testing was not performed during the initial work-up. When they were subjected to exercise stress testing during follow-up, a delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia (CPVT) was made. As a result, these patients were initially managed inappropriately, and their family members were initially not screened for CPVT. Conclusion: In sudden cardiac arrest survivors without an immediately identifiable cause, omission of exercise stress testing or erroneous interpretation of the results can lead to a delayed or missed diagnosis of CPVT, which may have considerable implications for survivors and their family.
KW - CPVT
KW - Exercise stress testing
KW - Sudden cardiac arrest
UR - http://www.scopus.com/inward/record.url?scp=85162634562&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s12471-023-01789-w
DO - https://doi.org/10.1007/s12471-023-01789-w
M3 - Article
C2 - 37347419
SN - 1568-5888
VL - 31
SP - 444
EP - 451
JO - Netherlands heart journal
JF - Netherlands heart journal
IS - 11
ER -