Importance of timing of radiotherapy in breast conserving treatment for early stage breast cancer

B J Slotman, O W Meyer, K H Njo, A B Karim

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8 Citations (Scopus)


This study reports on the treatment results in 508 patients with 514 AJCC stage I-II invasive breast carcinomas treated between July 1980 and July 1989. All patients underwent a lumpectomy with axillary lymph node dissection with postoperative irradiation. Adjuvant chemotherapy was given to premenopausal node-positive patients. Postmenopausal node-positive patients received adjuvant hormonal treatment. The median follow-up period was 68 months (range, 40-152 months). The 5-year survival rates were 92.6%, 81.4% and 65.5% for stage I, stage IIA and stage IIB, respectively. Distant metastases were the main cause of death. Locoregional failures occurred in 4.9%. Breast recurrences were detected in 17 patients (3.3%). In a Cox proportional hazards analysis, T-stage, pathological margins and interval between surgery and radiotherapy were identified as independent factors predictive of breast recurrence (p < 0.05). The results suggest that radiotherapy should be initiated early after surgery to maintain the breast recurrence rate as low as possible.

Original languageEnglish
Pages (from-to)206-12
Number of pages7
JournalRadiotherapy and oncology
Issue number3
Publication statusPublished - Mar 1994


  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols/therapeutic use
  • Breast Neoplasms/drug therapy
  • Carcinoma, Ductal, Breast/radiotherapy
  • Carcinoma, Lobular/radiotherapy
  • Carcinoma/radiotherapy
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Lymph Node Excision
  • Lymphatic Irradiation
  • Mastectomy, Segmental
  • Middle Aged
  • Neoplasm Recurrence, Local/prevention & control
  • Neoplasm Staging
  • Radiotherapy Dosage
  • Radiotherapy, High-Energy
  • Survival Rate
  • Time Factors

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